MSc Thesis Defense: Ayşe Nilay Seyhan, INVESTIGATING THE TRANSLATIONAL MECHANISM OF ANDROGEN RECEPTOR IN PROSTATE CANCER, Date & Time: June 24, 2026 – 2:00 PM, Place: FENS G032
INVESTIGATING THE TRANSLATIONAL MECHANISM OF ANDROGEN RECEPTOR IN PROSTATE CANCER
Ayşe Nilay Seyhan
Molecular Biology, Genetics, and Bioengineering, MSc Thesis, 2026
Thesis Jury
Asst. Prof. Duygu Kuzuoğlu Öztürk (Thesis Advisor)
Assoc. Prof. Umut Şahin
Assoc. Prof. Nathan A. Lack
Date & Time: June 24th, 2026 – 02:00 PM
Place: FENS G032
Zoom: https://sabanciuniv.zoom.us/j/
Meeting ID: 959 8352 2598
Keywords: Translation, Androgen Receptor, Ribosome Stalling, Prostate Cancer
Abstract
Prostate cancer is one of the leading causes of cancer-related diseases in men and is primarily driven by androgen receptor (AR) signaling. Although androgen deprivation therapy is initially effective, many patients develop castration-resistant prostate cancer (CRPC), a more aggressive form of prostate cancer, often mediated by AR splice variants such as ARv7. While transcriptional regulation of AR has been extensively studied, the mechanisms controlling AR translation remain poorly understood. Recent findings suggest that translational control may represent a promising therapeutic target in CRPC. Translation elongation is especially critical for the mRNAs containing complex coding sequences, such as AR, and can be disrupted by ribosome stalling events. Ribosome-associated Quality Control pathways, involving key factors such as ZNF598, ASCC3, and LTN1, detect and resolve stalled ribosomes to maintain translational homeostasis and proteostasis. Dysregulation of these pathways has been implicated in cancer cell adaptation to stress conditions. In this study, the relationship between AR mRNA translation elongation and ribosome-associated quality control was investigated, and it was assessed whether this machinery resolves ribosome-stalling events occurring during AR synthesis in CRPC cells.