Introduction to biomaterials science and biocompatibility. Structure and properties of tissues and cells. Surface properties of materials and characterization of biomaterials surfaces. Classes of materials used in medicine: Metals, polymers, hydrogels, bioresorbable materials, ceramics, glasses, composites, thin films, fabrics and biologically functional materials. Microscopic and macroscopic structure of tissue. Mechanical properties of tissue. Pathobiological responses to implants. Medical implant design and function. Application of materials in medicine and dentistry. Cardiovascular applications. Dental implants. Orthopaedic applications. Ophthalmologic applications. Sutures. Adhesives and sealants. Tissue engineering.
Biomaterials Science and Biocompatibility (MAT 416)
2022 Spring
Faculty of Engineering and Natural Sciences
Materials Sci.& Nano Eng.(MAT)
3
6/5 ECTS (for students admitted in the 2013-14 Academic Year or following years)
Gözde İnce gozdeince@sabanciuniv.edu,
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English
Undergraduate
--
Formal lecture,Interactive lecture
Discussion based learning,Project based learning,Task based learning
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| Programs\Type | Required | Core Elective | Area Elective |
| Materials Science and Nano Engineering | * | ||
| Materials Science and Nano Engineering (Previous Name: Materials Science and Engineering) | * | ||
| Microelectronics | * | ||
| Molecular Biology, Genetics and Bioengineering | * | ||
| Molecular Biology, Genetics and Bioengineering (Pre. Name: Biological Sciences and Bioengineering) | * | ||
| Telecommunications | * |
CONTENT
OBJECTIVE
To understand the basic principles of biology and materials design (ceramics, polymers, metals, composites thereof), processing, testing, and characterization as is pertains to the immune response, foreign body reaction, healing versus infection & tissue engineering.
LEARNING OUTCOMES
- Upon successful completion of Biomaterials and Biocompatibility (MAT416), students are expected to: Describe the principle types, structure, testing and properties of biomaterials,
- Discuss the interplay between biomaterials and the body at various stages following contact/implantation,
- Compare a normal implant healing process against adverse scenarios such as an allergic foreign body reaction,
- List the preservation techniques of biomaterials
- Discuss the potential of tissue engineering and the potential influence of physico-chemical-mechanical actuation on the state of an implanted scaffold
PROGRAMME OUTCOMES
1. Understand the world, their country, their society, as well as themselves and have awareness of ethical problems, social rights, values and responsibility to the self and to others. 1
2. Understand different disciplines from natural and social sciences to mathematics and art, and develop interdisciplinary approaches in thinking and practice. 1
3. Think critically, follow innovations and developments in science and technology, demonstrate personal and organizational entrepreneurship and engage in life-long learning in various subjects; have the ability to continue to educate him/herself. 3
4. Communicate effectively in Turkish and English by oral, written, graphical and technological means. 4
5. Take individual and team responsibility, function effectively and respectively as an individual and a member or a leader of a team; and have the skills to work effectively in multi-disciplinary teams. 4
1. Possess sufficient knowledge of mathematics, science and program-specific engineering topics; use theoretical and applied knowledge of these areas in complex engineering problems. 4
2. Identify, define, formulate and solve complex engineering problems; choose and apply suitable analysis and modeling methods for this purpose. 3
3. Develop, choose and use modern techniques and tools that are needed for analysis and solution of complex problems faced in engineering applications; possess knowledge of standards used in engineering applications; use information technologies effectively. 3
4. Have the ability to design a complex system, process, instrument or a product under realistic constraints and conditions, with the goal of fulfilling specified needs; apply modern design techniques for this purpose. 4
5. Design and conduct experiments, collect data, analyze and interpret the results to investigate complex engineering problems or program-specific research areas. 1
6. Possess knowledge of business practices such as project management, risk management and change management; awareness on innovation; knowledge of sustainable development. 1
7. Possess knowledge of impact of engineering solutions in a global, economic, environmental, health and societal context; knowledge of contemporary issues; awareness on legal outcomes of engineering solutions; knowledge of behavior according to ethical principles, understanding of professional and ethical responsibility. 1
8. Have the ability to write effective reports and comprehend written reports, prepare design and production reports, make effective presentations, and give and receive clear and intelligible instructions. 4
1. Comprehend key concepts in biology and physiology, with emphasis on molecular genetics, biochemistry and molecular and cell biology as well as advanced mathematics and statistics. 2
2. Develop conceptual background for interfacing of biology with engineering for a professional awareness of contemporary biological research questions and the experimental and theoretical methods used to address them. 1
1. Applying fundamental and advanced knowledge of natural sciences as well as engineering principles to develop and design new materials and establish the relation between internal structure and physical properties using experimental, computational and theoretical tools. 3
2. Merging the existing knowledge on physical properties, design limits and fabrication methods in materials selection for a particular application or to resolve material performance related problems. 5
3. Predicting and understanding the behavior of a material under use in a specific environment knowing the internal structure or vice versa. 4
Update Date:
ASSESSMENT METHODS and CRITERIA
| Percentage (%) | |
| Final | 50 |
| Midterm | 25 |
| Group Project | 25 |
RECOMENDED or REQUIRED READINGS
| Readings |
There are at least 30 excellent books related to biomaterials, biocompatibility, and tissue engineering, as well as an arsenal of journal references and Internet sources. Examples: Advances in Biomaterials, S.M. Lee (Ed.), Technomic, Lancaster, PA, 1987. Journals Internet |