1)The lectures will cover aspects of several rare diseases, common infectious viral diseases and multifactorial diseases like AMD. 2)The outcome of disease mutations for protein-protein or protein-nucleic acid interactions and protein functions at the molecular level will be coupled with model organism studies and its consequences for tissues, organs and the whole animal. 3)Both failed and successful therapeutic approaches for a given disease condition will be discussed. Moreover, where available, ongoing clinical trials and the discussion of its disease mechanism and the therapautic aproach that is used will be a part of the course. 4)A short essay will be written covering the etiology, diagnostics and ongoing or possble therapautic appraoches of a given disease. Disease condition will be decided by students at 7th week of the course
Special Topics in BIO: Gene Regulation and Disease (BIO 48006)
Programs\Type | Required | Core Elective | Area Elective |
Computer Science and Engineering | * | ||
Computer Science and Engineering | * | ||
Electronics Engineering | * | ||
Electronics Engineering | * | ||
Industrial Engineering | * | ||
Industrial Engineering (Previous Name: Manufacturing Systems Engineering) | * | ||
Materials Science and Nano Engineering | * | ||
Materials Science and Nano Engineering (Previous Name: Materials Science and Engineering) | * | ||
Mechatronics Engineering | * | ||
Mechatronics Engineering | * | ||
Microelectronics | * | ||
Molecular Biology, Genetics and Bioengineering | * | ||
Molecular Biology, Genetics and Bioengineering (Pre. Name: Biological Sciences and Bioengineering) | * | ||
Telecommunications | * |
CONTENT
OBJECTIVE
Nowadays, medicine is in a transformation stage where classical drug treatments are slowly getting replaced by approaches like personalized medicine and gene therapy. Therefore, therapies are requiring more and more in depth knowledge of molecular biology and to be able make connections with more advanced techniques and the etiology of the disease that is studied. This course will provide advanced level of training and understanding of the molecular mechanisms of diseases by focusing on gene regulatory mechanisms like chromatin remodeling and mRNA transcription, RNA splicing, as well as post-transcriptional and post-translational mechanisms. The course will also focus on gene regulatory and gene correction tools for therapeutic approaches like dCas9, TALE, Zinc finger, CasRX, Cas13a and base editing The course will complement the understanding of basic research findings and their outcomes in animal models and thus their consequences on the whole organism.
Update Date:
ASSESSMENT METHODS and CRITERIA
Percentage (%) | |
Term-Paper | 40 |
Participation | 20 |
Presentation | 40 |