1)The lectures will cover aspects of several rare diseases, common infectious viral diseases and multifactorial diseases like AMD. 2)The outcome of disease mutations for protein-protein or protein-nucleic acid interactions and protein functions at the molecular level will be coupled with model organism studies and its consequences for tissues, organs and the whole animal. 3)Both failed and successful therapeutic approaches for a given disease condition will be discussed. Moreover, where available, ongoing clinical trials and the discussion of its disease mechanism and the therapautic aproach that is used will be a part of the course. 4)A short essay will be written covering the etiology, diagnostics and ongoing or possble therapautic appraoches of a given disease. Disease condition will be decided by students at 7th week of the course
Special Topics in BIO: Gene Regulation and Disease (BIO 58006)
Programs\Type | Required | Core Elective | Area Elective |
Computer Science and Engineering - With Bachelor's Degree | * | ||
Computer Science and Engineering - With Master's Degree | * | ||
Computer Science and Engineering - With Thesis | * | ||
Cyber Security - With Bachelor's Degree | * | ||
Cyber Security - With Master's Degree | * | ||
Cyber Security - With Thesis | * | ||
Data Science - With Thesis | * | ||
Electronics Engineering and Computer Science - With Bachelor's Degree | * | ||
Electronics Engineering and Computer Science - With Master's Degree | * | ||
Electronics Engineering and Computer Science - With Thesis | * | ||
Electronics Engineering - With Bachelor's Degree | * | ||
Electronics Engineering - With Master's Degree | * | ||
Electronics Engineering - With Thesis | * | ||
Energy Technologies and Management-With Thesis | * | ||
Industrial Engineering - With Bachelor's Degree | * | ||
Industrial Engineering - With Master's Degree | * | ||
Industrial Engineering - With Thesis | * | ||
Leaders for Industry Biological Sciences and Bioengineering - Non Thesis | * | ||
Leaders for Industry Computer Science and Engineering - Non Thesis | * | ||
Leaders for Industry Electronics Engineering and Computer Science - Non Thesis | * | ||
Leaders for Industry Electronics Engineering - Non Thesis | * | ||
Leaders for Industry Industrial Engineering - Non Thesis | * | ||
Leaders for Industry Materials Science and Engineering - Non Thesis | * | ||
Leaders for Industry Mechatronics Engineering - Non Thesis | * | ||
Manufacturing Engineering - Non Thesis | * | ||
Manufacturing Engineering - With Bachelor's Degree | * | ||
Manufacturing Engineering - With Master's Degree | * | ||
Manufacturing Engineering - With Thesis | * | ||
Materials Science and Nano Engineering-(Pre:Materials Science and Engineering) | * | ||
Materials Science and Nano Engineering-(Pre:Materials Science and Engineering) | * | ||
Materials Science and Nano Engineering - With Thesis (Pre.Name: Materials Science and Engineering) | * | ||
Mathematics - With Bachelor's Degree | * | ||
Mathematics - With Master's Degree | * | ||
Mathematics - With Thesis | * | ||
Mechatronics Engineering - With Bachelor's Degree | * | ||
Mechatronics Engineering - With Master's Degree | * | ||
Mechatronics Engineering - With Thesis | * | ||
Molecular Biology, Genetics and Bioengineering (Prev. Name: Biological Sciences and Bioengineering) | * | ||
Molecular Biology, Genetics and Bioengineering-(Prev. Name: Biological Sciences and Bioengineering) | * | ||
Molecular Biology,Genetics and Bioengineering-With Thesis (Pre.Name:Biological Sciences and Bioeng.) | * | ||
Physics - Non Thesis | * | ||
Physics - With Bachelor's Degree | * | ||
Physics - With Master's Degree | * | ||
Physics - With Thesis | * |
CONTENT
OBJECTIVE
Nowadays, medicine is in a transformation stage where classical drug treatments are slowly getting replaced by approaches like personalized medicine and gene therapy. Therefore, therapies are requiring more and more in depth knowledge of molecular biology and to be able make connections with more advanced techniques and the etiology of the disease that is studied. This course will provide advanced level of training and understanding of the molecular mechanisms of diseases by focusing on gene regulatory mechanisms like chromatin remodeling and mRNA transcription, RNA splicing, as well as post-transcriptional and post-translational mechanisms. The course will also focus on gene regulatory and gene correction tools for therapeutic approaches like dCas9, TALE, Zinc finger, CasRX, Cas13a and base editing The course will complement the understanding of basic research findings and their outcomes in animal models and thus their consequences on the whole organism.
Update Date:
ASSESSMENT METHODS and CRITERIA
Percentage (%) | |
Term-Paper | 40 |
Participation | 20 |
Presentation | 40 |