Biomaterials Science and Biocompatibility (MAT 516)

2021 Spring
Faculty of Engineering and Natural Sciences
Materials Sci.& Nano Eng.(MAT)
Gözde İnce,
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Doctoral, Master
Formal lecture,Interactive lecture
Interactive,Discussion based learning,Project based learning
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Introduction to biomaterials science and biocompatibility. Structure and properties of tissues and cells. Surface properties of materials and characterization of biomaterials surfaces. Classes of materials used in medicine: Metals, polymers, hydrogels, bioresorbable materials, ceramics, glasses, composites, thin films, fabrics and biologically functional materials. Microscopic and macroscopic structure of tissue. Mechanical properties of tissue. Pathobiological responses to implants. Medical implant design and function. Application of materials in medicine and dentistry. Cardiovascular applications. Dental implants. Orthopaedic applications. Ophthalmologic applications. Sutures. Adhesives and sealants. Tissue engineering.


To understand the basic principles of biology and materials design (ceramics, polymers, metals, composites thereof), processing, testing, and characterization as is pertains to the immune response, foreign body reaction, healing versus infection & tissue engineering.


Upon successful completion of Biomaterials and Biocompatibility (MAT516), students are expected to:
- Describe the principle types, structure, testing and properties of biomaterials,
- Discuss the interplay between biomaterials and the body at various stages following contact/implantation,
- Compare a normal implant healing process against adverse scenarios such as an allergic foreign body reaction,
- List the preservation techniques of biomaterials
- Discuss the potential of tissue engineering and the potential influence of physico-chemical-mechanical actuation on the state of an implanted scaffold


  Percentage (%)
Final 40
Midterm 30
Group Project 30



There are at least 30 excellent books related to biomaterials, biocompatibility, and tissue engineering, as well as an arsenal of journal references and Internet sources. Examples:

Advances in Biomaterials, S.M. Lee (Ed.), Technomic, Lancaster, PA, 1987.
Biomaterials; SV Bhat, Kluwer Academic Publishers, 2002
Biological Performance of Materials; J Black, Marcel Dekker, Inc, 1999
Bio-Implant Interface; JE Ellingsen, SP Lyngstadaas, CRC Press 2003
Principles of Tissue Engineering; RP Lanza, R Langer, J Vacanti, Academic Press, 2000
Biomaterials: An Introduction; JB Park, RS Lakes, Plenum Press, 1992
Biomaterials: Principles and Applications; JB Park, JD Bronzino, CRC Press, 2003
Frontiers in Tissue Engineering; CW Patrick, AG Mikos, LV McIntire, Pergamon, 1998
Biomaterials and Bioengineering Handbook; DL Wise, Marcel Dekker Inc., 2000
Biocompatibility in Clinical Practice, Boca Raton, FL, CRC Press, 1982
Orthopaedic Biomaterials; J Black, Churchill Livingstone, 1988

Acta Orthopaedica Scandinavica, American Association of Artificial Internal Organs: Transactions, Annals of Biomedical Engineering, Applied Biomaterials, Biomaterials, Biomedical Engineering, Biomedical Materials and Engineering, Biomedical Microdevices, Biopolymers, Clinical Orthopaedics and Related Research, CRC Critical Review in Bioengineering, International Orthopaedics, Journal of Applied Biomaterials, Journal of Arthoplasty, Journal of Biomechanics, Journal of Biomedical Engineering, Journal of Biomedical Materials Research, Journal of Bone and Joint Surgery, Journal of Medical Engineering and Technology, Journal of Orthopaedic Research, Medical Engineering and Physics, Tissue Engineering, Transactions of the American Society of Artificial Internal Organs (held annually in spring): Extended Abstracts, Transactions of the Orthopaedic Research Society Meeting (held annually during February): Abstracts, Transactions of the Society for Biomaterials (held annually during April and May): Abstracts

Society for Biomaterials: