Structural Biology (BIO 532)

2021 Spring
Faculty of Engineering and Natural Sciences
Mol.Bio.Genetic&Bioengin.(BIO)
3
10.00
Canan At─▒lgan -canan@sabanciuniv.edu,
English
Doctoral, Master
--
Formal lecture,Interactive lecture,Seminar
Interactive,Learner centered,Communicative,Discussion based learning,Project based learning,Simulation,Case Study
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CONTENT

Approaches used in 3D structure determination of biological macromolecules as well as those used in determination of larger structures in cells will be discussed. Topics include X-ray spectroscopy and crystallography, nuclear magnetic resonance spectroscopy, time-resolved measurements using X-ray solution scattering. For larger structures microscopic techniques including electron and fluorescence microscopy and indirect imaging methods will be discussed.

OBJECTIVE

To equip the students with (i) a basic understanding of structure - function relationships in biological macromolecules, (ii) convey the fundamental principles of experimental and computational techniques utilized for this purpose, (iii) reconsider evolution from the perspective of molecular structures.

LEARNING OUTCOME

After completing the teaching and learning activities associated with this course, students should be able to:

a) Identify the basic concepts in structural biology
b) Describe the range and structures of biological molecules
c) Describe the relationship between chemical structure and biological function
d) Identify essential facts and theory of structural methods used for biological macromolecules
e) Identify essential facts and theory in structural organization in biological macromolecules.
f) Identify essential facts and theory in a sub-discipline of the biosciences.
g) Evaluate aspects of the biosciences with reference to textbooks.
h) With some guidance, deploy established techniques of analysis, practical investigation, and enquiry within the biosciences.
i) Communicate ideas effectively by written means.
j) With some guidance, study autonomously.
k) With some guidance, organize information drawn from books.

ASSESSMENT METHODS and CRITERIA

  Percentage (%)
Final 30
Midterm 25
Individual Project 35
Presentation 10

RECOMENDED or REQUIRED READINGS

Readings

1. Branden and Tooze, Introduction to Protein Structure, 2nd edition, Garland Science, 1999.
2. Bahar, Jernigan and Dill, Protein Actions, Taylor & Francis, 2017.
3. Petsko and Ringe, Protein Structure and Function, New Science Press, 2004.