Approaches used in 3D structure determination of biological macromolecules as well as those used in determination of larger structures in cells will be discussed. Topics include X-ray spectroscopy and crystallography, nuclear magnetic resonance spectroscopy, time-resolved measurements using X-ray solution scattering. For larger structures microscopic techniques including electron and fluorescence microscopy and indirect imaging methods will be discussed.
Structural Biology (BIO 532)
Programs\Type | Required | Core Elective | Area Elective |
MA-European Studies | |||
MA-European Studies-Non Thesis | |||
MA-Political Science | |||
MA-Political Science-Non Thes | |||
MA-Visual Arts&Vis. Com Des-NT | |||
MA-Visual Arts&Visual Com Des | |||
MS-Bio. Sci. & Bioeng. LFI | |||
MS-Bio. Sci. & Bioeng. LFI-ENG | |||
MS-Biological Sci&Bioeng. | * | ||
MS-Computer Sci.&Eng. LFI | |||
MS-Computer Sci.&Eng. LFI-ENG | |||
MS-Computer Science and Eng. | * | ||
MS-Cyber Security(with thesis) | * | ||
MS-Data Science | |||
MS-Elec. Eng&Comp Sc.LFI-ENG | |||
MS-Electronics Eng&Comp Sc.LFI | |||
MS-Electronics Eng&Computer Sc | * | ||
MS-Electronics Eng. | * | ||
MS-Electronics Eng. LFI | |||
MS-Electronics Eng. LFI-ENG | |||
MS-Energy Techno.&Man. | * | ||
MS-Industrial Eng. LFI-ENG | |||
MS-Industrial Engineering | * | ||
MS-Industrial Engineering LFI | |||
MS-Manufacturing Eng-Non Thes | * | ||
MS-Manufacturing Engineering | * | ||
MS-Materials Sci & Engineering | * | ||
MS-Materials Sci. & Eng. LFI | |||
MS-Materials Sci.&Eng. LFI-ENG | |||
MS-Mathematics | |||
MS-Mechatronics | * | ||
MS-Mechatronics LFI | |||
MS-Mechatronics LFI-ENG | |||
MS-Physics | |||
MS-Physics-Non Thesis | * | ||
MS-Psychology | |||
MS-Psychology-Non Thesis | |||
PHD-Biological Sci&Bioeng. | * | ||
PHD-Comp. Sci and Eng.after UG | * | ||
PHD-Computer Science and Eng. | * | ||
PHD-Cyber Security | * | ||
PHD-Electronics Eng&ComputerSc | * | ||
PHD-Electronics Eng. | * | ||
PHD-Electronics Eng. after UG | * | ||
PHD-Experimental Psychology | |||
PHD-Industrial Engineering | * | ||
PHD-Management | |||
PHD-Manufacturing Eng after UG | * | ||
PHD-Manufacturing Engineering | * | ||
PHD-Materials Sci.&Engineering | |||
PHD-Mathematics | |||
PHD-Mechatronics | * | ||
PHD-Mechatronics after UG | * | ||
PHD-Physics | |||
PHD-Physics after UG | |||
PHD-Social Psychology | |||
PHDBIO after UG | * | ||
PHDCYSEC after UG | * | ||
PHDEECS after UG | * | ||
PHDEPSY after UG | |||
PHDIE after UG | * | ||
PHDMAN after UG | |||
PHDMAN after UG-Finance | |||
PHDMAN after UG-Man. and Org. | |||
PHDMAN after UG-Op.&Sup. Cha. | |||
PHDMAN-Finance Area | |||
PHDMAN-Man. and Org. Area | |||
PHDMAN-Op. & Supp. Chain Area | |||
PHDMAT after UG | * | ||
PHDMATH after UG | |||
PHDSPSY after UG |
CONTENT
OBJECTIVE
To equip the students with (i) a basic understanding of structure - function relationships in biological macromolecules, (ii) convey the fundamental principles of experimental and computational techniques utilized for this purpose, (iii) reconsider evolution from the perspective of molecular structures.
LEARNING OUTCOME
After completing the teaching and learning activities associated with this course, students should be able to:
a) Identify the basic concepts in structural biology
b) Describe the range and structures of biological molecules
c) Describe the relationship between chemical structure and biological function
d) Identify essential facts and theory of structural methods used for biological macromolecules
e) Identify essential facts and theory in structural organization in biological macromolecules.
f) Identify essential facts and theory in a sub-discipline of the biosciences.
g) Evaluate aspects of the biosciences with reference to textbooks.
h) With some guidance, deploy established techniques of analysis, practical investigation, and enquiry within the biosciences.
i) Communicate ideas effectively by written means.
j) With some guidance, study autonomously.
k) With some guidance, organize information drawn from books.
Update Date:
ASSESSMENT METHODS and CRITERIA
Percentage (%) | |
Final | 30 |
Midterm | 25 |
Individual Project | 35 |
Presentation | 10 |
RECOMENDED or REQUIRED READINGS
Readings |
1. Branden and Tooze, Introduction to Protein Structure, 2nd edition, Garland Science, 1999. |