Biology of Aging (BIO 446)

2021 Spring
Faculty of Engineering and Natural Sciences
Mol.Bio.Genetic&Bioengin.(BIO)
3
6.00 / 6.00 ECTS (for students admitted in the 2013-14 Academic Year or following years)
Alex Lyakhovich alex.lyakhovich@sabanciuniv.edu,
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English
Undergraduate
--
Formal lecture,Interactive lecture,Workshop,Group tutorial,Other
Interactive,Communicative,Discussion based learning,Task based learning,Guided discovery,Simulation,Other
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CONTENT

The course intends to provide an up-to- date overview of the field of aging and gerontology. While all of us intuitively know what the aging is, many basic questions about aging are mysterious. Is aging itself a disease, and can we successfully intervene in the aging process? Or is it a program that one can hack? The course will start with a discussion of aging systems both from the view of biologist but also from the point of view of a system engenderer. We will explore the scientific discoveries made from studies of model organisms, which have led to revelations about the molecular biology of aging. We will look at aging at different angles ? from population genetics to the ?reliability theory?. The second part of the course will describe methods for studying aging, descriptions of population aging, and theories on how and why we age. We are going to understand why older people more likely to experience neurodegenerative disorders, stroke, and cancer and what kind of changes happen at the molecular and cellular levels that are associated with these diseases. The third part of the course provides an in depth discussion of the processes of aging in various body systems. In combination with this we will discuss some medical treatments that can extend the lifespan of organisms as diverse as yeast and primates, and the implications for successfully intervening in age-related diseases. Finally students will explore biological changes that occur with aging at the molecular and organismal levels and how they can be viewed from the perspectives of various disciplines.

OBJECTIVE

The course intends to provide an up-to-date overview of the biology of aging, one of
the fastest growing scientific disciplines of the 21st century, located at the intersection of
biology, mathematics, computer science and medicine. Students who complete this course (ı) will gain knowledge regarding developmental changes as they occur during the aging process; (ıı) will be able to evaluate current issues related to the aging process; (ııı) will be able to apply the above knowledge in their chosen areas of professional development.

ASSESSMENT METHODS and CRITERIA

  Percentage (%)
Final 40
Midterm 30
Exam 30
Assignment 0

RECOMENDED or REQUIRED READINGS

Textbook

9780128162835 (we have 6th Edition in SU information unit, also OK)
Biology of Aging, 2nd Edition, Roger B. McDonald ISBN 9780815345671
Fortunately, or unfortunately, no good textbooks on aging have yet been written.
Therefore, the above handbooks supplement rather than replace the lectures.

Readings

All materials for home reading will be provided.

Optional Readings

Short videos will be attached to each lecture for your home watching.
Optional reading can be found at the very end of the lecture slides.