Biological Function and Structure (BIO 304)

2021 Spring
Faculty of Engineering and Natural Sciences
Mol.Bio.Genetic&Bioengin.(BIO)
3
6.00 / 6.00 ECTS (for students admitted in the 2013-14 Academic Year or following years)
Canan At─▒lgan -canan@sabanciuniv.edu,
English
Undergraduate
--
Formal lecture,Interactive lecture,Seminar,Group tutorial
Interactive,Communicative,Discussion based learning,Task based learning,Simulation
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CONTENT

The course will treat the chemistry and structure of biological molecules as a basis for understanding and predicting their function as nanomachines. Emphasis will be on proteins and their interactions, structural transitions, ligand interactions and analysis of the structural changes that lead to reactivity, stability, and accomplishment of the function.

OBJECTIVE

To equip the students with (i) a basic understanding of structure - function relationships in biological macromolecules, (ii) convey the fundamental principles of experimental and computational techniques utilized for this purpose, (iii) reconsider evolution from the perspective of molecular structures.

LEARNING OUTCOME

Upon successful completion of this course students are expected to:

Describe the basic steps in using X-ray crystallography for determination of macromolecular structure
Describe the basic ideas behind using NMR spectroscopy for determination of protein structures
Be aware of the fact that NMR experiments can be used to acquire information about the dynamics of the macromolecule on various time scales
Have a basic understanding of how molecular dynamics simulations of biomolecules work
Utilize available software for visualizing the structure of biomolecules
Understand the source and magnitude of the physical driving forces responsible for the spontaneous folding and interactions of biomolecules
Read and understand the main ideas of a research article in the field of structural biology
Present coherently, using the correct terminology, the findings of a research article in the field of structural biology that they may have read.

ASSESSMENT METHODS and CRITERIA

  Percentage (%)
Final 30
Midterm 25
Assignment 15
Participation 10
Presentation 20

RECOMENDED or REQUIRED READINGS

Readings

1. Branden and Tooze, Introduction to Protein Structure, 2nd edition, Garland Science, 1999.
2. Bahar, Jernigan and Dill, Protein Actions, Taylor & Francis, 2017.
3. Petsko and Ringe, Protein Structure and Function, New Science Press, 2004.