Biomaterials Science and Biocompatibility (MAT 416)

2020 Spring
Faculty of Engineering and Natural Sciences
Materials Sci.& Nano Eng.(MAT)
6.00 / 5.00 ECTS (for students admitted in the 2013-14 Academic Year or following years)
Gözde İnce,
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Formal lecture,Interactive lecture
Discussion based learning,Project based learning,Task based learning
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Introduction to biomaterials science and biocompatibility. Structure and properties of tissues and cells. Surface properties of materials and characterization of biomaterials surfaces. Classes of materials used in medicine: Metals, polymers, hydrogels, bioresorbable materials, ceramics, glasses, composites, thin films, fabrics and biologically functional materials. Microscopic and macroscopic structure of tissue. Mechanical properties of tissue. Pathobiological responses to implants. Medical implant design and function. Application of materials in medicine and dentistry. Cardiovascular applications. Dental implants. Orthopaedic applications. Ophthalmologic applications. Sutures. Adhesives and sealants. Tissue engineering.


To understand the basic principles of biology and materials design (ceramics, polymers, metals, composites thereof), processing, testing, and characterization as is pertains to the immune response, foreign body reaction, healing versus infection & tissue engineering.


Upon successful completion of Biomaterials and Biocompatibility (MAT416), students are expected to:
- Describe the principle types, structure, testing and properties of biomaterials,
- Discuss the interplay between biomaterials and the body at various stages following contact/implantation,
- Compare a normal implant healing process against adverse scenarios such as an allergic foreign body reaction,
- List the preservation techniques of biomaterials
- Discuss the potential of tissue engineering and the potential influence of physico-chemical-mechanical actuation on the state of an implanted scaffold


1. Understand the world, their country, their society, as well as themselves and have awareness of ethical problems, social rights, values and responsibility to the self and to others. 3

2. Understand different disciplines from natural and social sciences to mathematics and art, and develop interdisciplinary approaches in thinking and practice. 5

3. Think critically, follow innovations and developments in science and technology, demonstrate personal and organizational entrepreneurship and engage in life-long learning in various subjects. 5

4. Communicate effectively in Turkish and English by oral, written, graphical and technological means. 4

5. Take individual and team responsibility, function effectively and respectively as an individual and a member or a leader of a team; and have the skills to work effectively in multi-disciplinary teams. 4

1. Possess sufficient knowledge of mathematics, science and program-specific engineering topics; use theoretical and applied knowledge of these areas in complex engineering problems.

2. Identify, define, formulate and solve complex engineering problems; choose and apply suitable analysis and modeling methods for this purpose.

3. Develop, choose and use modern techniques and tools that are needed for analysis and solution of complex problems faced in engineering applications; possess knowledge of standards used in engineering applications; use information technologies effectively.

4. Ability to design a complex system, process, instrument or a product under realistic constraints and conditions, with the goal of fulfilling specified needs; apply modern design techniques for this purpose.

5. Design and conduct experiments, collect data, analyze and interpret the results to investigate complex engineering problems or program-specific research areas.

6. Knowledge of business practices such as project management, risk management and change management; awareness on innovation; knowledge of sustainable development.

7. Knowledge of impact of engineering solutions in a global, economic, environmental, health and societal context; knowledge of contemporary issues; awareness on legal outcomes of engineering solutions; understanding of professional and ethical responsibility.

1. Comprehend key concepts in biology and physiology, with emphasis on molecular genetics, biochemistry and molecular and cell biology as well as advanced mathematics and statistics.

2. Develop conceptual background for interfacing of biology with engineering for a professional awareness of contemporary biological research questions and the experimental and theoretical methods used to address them.

1. Applying fundamental and advanced knowledge of natural sciences as well as engineering principles to develop and design new materials and establish the relation between internal structure and physical properties using experimental, computational and theoretical tools.

2. Merging the existing knowledge on physical properties, design limits and fabrication methods in materials selection for a particular application or to resolve material performance related problems.

3. Predicting and understanding the behavior of a material under use in a specific environment knowing the internal structure or vice versa.


  Percentage (%)
Final 30
Midterm 40
Group Project 30



There are at least 30 excellent books related to biomaterials, biocompatibility, and tissue engineering, as well as an arsenal of journal references and Internet sources. Examples:

Advances in Biomaterials, S.M. Lee (Ed.), Technomic, Lancaster, PA, 1987.
Biomaterials; SV Bhat, Kluwer Academic Publishers, 2002
Biological Performance of Materials; J Black, Marcel Dekker, Inc, 1999
Bio-Implant Interface; JE Ellingsen, SP Lyngstadaas, CRC Press 2003
Principles of Tissue Engineering; RP Lanza, R Langer, J Vacanti, Academic Press, 2000
Biomaterials: An Introduction; JB Park, RS Lakes, Plenum Press, 1992
Biomaterials: Principles and Applications; JB Park, JD Bronzino, CRC Press, 2003
Frontiers in Tissue Engineering; CW Patrick, AG Mikos, LV McIntire, Pergamon, 1998
Biomaterials and Bioengineering Handbook; DL Wise, Marcel Dekker Inc., 2000
Biocompatibility in Clinical Practice, Boca Raton, FL, CRC Press, 1982
Orthopaedic Biomaterials; J Black, Churchill Livingstone, 1988

Acta Orthopaedica Scandinavica, American Association of Artificial Internal Organs: Transactions, Annals of Biomedical Engineering, Applied Biomaterials, Biomaterials, Biomedical Engineering, Biomedical Materials and Engineering, Biomedical Microdevices, Biopolymers, Clinical Orthopaedics and Related Research, CRC Critical Review in Bioengineering, International Orthopaedics, Journal of Applied Biomaterials, Journal of Arthoplasty, Journal of Biomechanics, Journal of Biomedical Engineering, Journal of Biomedical Materials Research, Journal of Bone and Joint Surgery, Journal of Medical Engineering and Technology, Journal of Orthopaedic Research, Medical Engineering and Physics, Tissue Engineering, Transactions of the American Society of Artificial Internal Organs (held annually in spring): Extended Abstracts, Transactions of the Orthopaedic Research Society Meeting (held annually during February): Abstracts, Transactions of the Society for Biomaterials (held annually during April and May): Abstracts

Society for Biomaterials: