Immunology (BIO 452)

2021 Fall
Faculty of Engineering and Natural Sciences
Mol.Bio.Genetic&Bioengin.(BIO)
3
6.00 / 6.00 ECTS (for students admitted in the 2013-14 Academic Year or following years)
Tunç Akkoç -tunc.akkoc@sabanciuniv.edu,
English
Undergraduate
NS201
Formal lecture,Interactive lecture
Interactive,Discussion based learning
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CONTENT

This is an introductory undergraduate course which surveys most areas of immunology. Immunology is the study of how higher organisms deal with infectious agents. The course is designed to provide a basic understanding of molecular mechanisms underlying the development of immune response. Topics will include molecular mechanisms of innate immunity, the structure of antibodies and T cell receptors, antigen- antibody interactions, the major histocompatibility complex, generation of diversity, antigen presentation, signaling through immune system receptors, the molecular basis of immune attack, immunological tolerance, and immune memory. There will be topics from medical or bench-side immunology in last few weeks, depends on the conditions and time availability.

OBJECTIVE

To teach the history and modern molecular, cellular and organismal concepts of immunology so that each student can begin to think like an immunologist.

LEARNING OUTCOME

Understand the evolutionary principles controlling the development and function of the immune system
Know the identity of different types of immune system cells, their functions and interactions
Understand the molecular biological mechanisms controlling antibody generation, the mechanisms of somatic VDJ recombination and somatic hypermutation
Differentiate between the function of the antibody isotypes produced by the mammalian immune system and the significance of the major histocompatibility complex
Detail the signal transduction events that govern cellular communication in the immune system
Understand the methods used in immunological research such as ELISA, Western blot, FLOW cytometry, bone marrow transplantation, mouse transgenesis and how to generate a knockout mouse.

ASSESSMENT METHODS and CRITERIA

  Percentage (%)
Final 50
Midterm 30
Participation 20

RECOMENDED or REQUIRED READINGS

Textbook

Janeway's Immunobiology
Edition: 8th Author(s):Kenneth Murphy ISBN: 9780815342434