Türkçe sürüm

Emrah Eroğlu

E-mail : emrah.eroglusabanciuniv.edu

Education :

2019-                  Principle Investigator (Sabanci University)

2017-2019           Postdoctoral Fellow (Harvard Medical School)

2016 -2017          Postdoctoral Fellow (MedUni Graz)

2015 -2016          PhD Student Molecular Medicine (Molecular Medicine Program, MedUni Graz)

2013-present       Medicine (Meduni Graz)

2012 -2015          Master’s degree in Biotechnology and Bioanalytics (Vienna University of Technology)

2012 -2012          Exam for nationally certified pharmaceutical representative (Ministry of Health, Austria).

2008 -2012          Bachelor’s degree in Biology and Molecular biology (Vienna University)

2007 -2008          University entrance exam (Vienna University)

Work Experience :

October 2017- September 2019, Senior Postdoctoral Fellow at Harvard Medical School)

December 2016 -October 2017, Junior Postdoctoral Fellow at MedUni Graz)

Areas of Interest :

Design and development of genetically encoded biosensors, High-resolution live-cell imaging, Nitric oxide biochemistry, Chemogenetic approaches, Cell physiology

Membership :

AHA American Heart Association, SFRR-E Society for Free Radical Research Europe, Austrian Association of Molecular Life Sciences and Biotechnology

Publications :

Sevimli, Gülşah and Alston, Amy E. and Funk, Felix and Flühmann, Beat and Malli, Roland and Graier, Wolfgang F. and Eroğlu, Emrah (2022) "Probing subcellular iron availability with genetically encoded nitric oxide biosensors", Biosensors, Vol.12, No.10 (SCI)
Pandey, Arvind K. and Waldeck-Weiermair, Markus and Wells, Quinn S. and Xiao, Wusheng and Yadav, Shambhu and Eroğlu, Emrah and Michel, Thomas and Loscalzo, Joseph (2022) "Expression of CD70 modulates nitric oxide and redox status in endothelial cells", Arteriosclerosis, Thrombosis, and Vascular Biology, Vol.42, No.9, 1169-1185 (SCI)
Sevimli, Gülşah and Smith, Matthew J. and Akgül Çağlar, Tüba and Bilir, Şükriye and Seçilmiş, Melike and Altun, Hamza Yusuf and Yigit, Esra N. and Yang, Fan and Keeley, Thomas P. and Malli, Roland and Öztürk, Gürkan and Mann, Giovanni E. and Eroğlu, Emrah (2022) "Nitric oxide biosensor uncovers diminished ferrous iron-dependency of cultured cells adapted to physiological oxygen levels", Redox Biology, Vol.53 (SCI)
Ghaffari Zaki, Asal and Erdoǧan, Yusuf C. and Akgül Çağlar, Tüba and Eroğlu, Emrah (2022) "Chemogenetic approaches to dissect the role of H2O2 in redox-dependent pathways using genetically encoded biosensors", Biochemical Society Transactions, Vol.50, No.1, 335-345 (SCI)
Steinhorn, Benjamin and Eroğlu, Emrah and Michel, Thomas (2022) "Chemogenetic approaches to probe redox pathways: implications for cardiovascular pharmacology and toxicology", Annual Review of Pharmacology and Toxicology, Vol.62, 551-571 (SCI)
Erdoğan, Yusuf Ceyhun and Altun, Hamza Yusuf and Seçilmiş, Melike and Ata, Büşra Nur and Sevimli, Gülşah and Çokluk, Zeynep and Ghaffari Zaki, Asal and Sezen, Serap and Akgul Caglar, Tuba and Sevgen, İlker and Steinhorn, Benjamin and Ai, Huiwang and Öztürk, Gürkan and Belousov, Vsevelod V. and Michel, Thomas and Eroğlu, Emrah (2021) "Complexities of the chemogenetic toolkit: differential mDAAO activation by D-amino substrates and subcellular targeting", Free Radical Biology and Medicine, Vol.177, 132-142 (SCI)
Seçilmiş, Melike and Altun, Hamza Yusuf and Pilic, Johannes and Erdoğan, Yusuf Ceyhun and Çokluk, Zeynep and Ata, Büşra Nur and Sevimli, Gülşah and Ghaffari Zaki, Asal and Yigit, Esra Nur and Öztürk, Gürkan and Malli, Roland and Eroğlu, Emrah (2021) "A co-culture-based multiparametric imaging technique to dissect local h2o2 signals with targeted hyper7", Biosensors, Vol.11, No.9 (SCI)
Collins, John A. and Kapustina, Maryna and Bolduc, Jesalyn A. and Pike, James F.W. and Diekman, Brian O. and Mix, Kimberlee and Chubinskaya, Susan and Eroğlu, Emrah and Michel, Thomas and Poole, Leslie B. and Furdui, Cristina M. and Loeser, Richard F. (2021) "Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes", Free Radical Biology and Medicine, Vol.166, 90-103 (SCI)
Papers in Conference Proceedings
Eroğlu, Emrah, "Multiparametric imaging approaches to dissect the role of ROS and eNOS signaling pathways using chemogenetic tools and genetically encoded biosensors", 45th FEBS Congress, Molecules of Life: Towards New Horizons, Wiley, July 2021, 51-51
Before SU Publications:
Eroglu E, Michel T, Graier W, Malli R. Yes (again) to local NO. Nature Chemical Biology volume 16, pages 606–607(2020) Seyed Soheil Saeedi Saravi*, Emrah Eroglu*, Markus Waldeck-Weiermair, Andrea Sorrentino, Benjamin Steinhorn, Vselovod Belousov, Thomas Michel (2020) Differential endothelial signaling responses elicited by chemogenetic H2O2 synthesis, Redox Biology, https://doi.org/10.1016/j.redox.2020.101605. Valeriy V.Pak, DariaEzeriņa, Olga G.Lyublinskaya, BrandánPedre, Pyotr A.Tyurin-Kuzmin, Natalie M.Mishina, MarionThauvin, DavidYoung, KhadijaWahni, Santiago AgustínMartínez Gache, Alexandra D.Demidovich, Yulia G.Ermakova, Yulia D.Maslova, Arina G.Shokhina, EmrahEroglu, Dmitry S.Bilan, IvanBogeski, ThomasMichel, SophieVriz, JorisMessens, Vsevolod V.Belousov (2020) Cell Metabolism Volume 31, Issue 3, 3 March 2020, Pages 642-653.e6 Ultrasensitive Genetically Encoded Indicator for Hydrogen Peroxide Identifies Roles for the Oxidant in Cell Migration and Mitochondrial Function

Markus Waldeck-Weiermair, Benjamin Gottschalk, Corina T Madreiter Sokolowski, Jeta Ramadani-Muja, Gabriella Ziomek, Christiane Klec, Sandra Burgstaller, Helmut Bischof, Maria R Depaoli, Emrah Eroglu, Roland Malli, Wolfgang F Graier, Front. Cell. Neurosci., 04 October 2019 | – Development and application of sub-mitochondrial targeted Ca2+ biosensors

Emrah Eroglu, Seyed Soheil Saeedi Saravi, Andrea Sorrentino, Benjamin Steinhorn, and Thomas Michel. Discordance between eNOS phosphorylation and activation revealed by multispectral imaging and chemogenetic approaches. 

Gottschalk B, Klec C, Leitinger G, Bernhart E, Rost R, Bischof H, Madreiter-Sokolowski CT, Radulović S, Eroglu E, Sattler W, Waldeck-Weiermair M, Malli R, Graier WF. MICU1 controls cristae junction and spatially anchors mitochondrial Ca(2+) uniporter complex. Nat Commun. 2019 Aug 19;10(1):3732. doi:  10.1038/s41467-019-11692-x. PubMed PMID: 31427612; PubMed Central PMCID: PMC6700202.

Sorrentino A, Steinhorn B, Troncone L, Saravi SSS, Badole S, Eroglu E, Kijewski MF, Divakaran S, Di Carli M, Michel T. Reversal of heart failure in a chemogenetic model of persistent cardiac redox stress. Am J Physiol Heart Circ Physiol. 2019 Sep 1;317(3):H617-H626. doi: 10.1152/ajpheart.00177.2019. Epub 2019 Jul 12. PubMed PMID: 31298558.

Depaoli MR, Bischof H, Eroglu E, Burgstaller S, Ramadani-Muja J, Rauter T, Schinagl M, Waldeck-Weiermair M, Hay JC, Graier WF, Malli R. Live cell imaging of signaling and metabolic activities. Pharmacol Ther. 2019 Jun 7. pii: S0163-7258(19)30110-X. doi: 10.1016/j.pharmthera.2019.06.003. [Epub ahead of print] Review. PubMed PMID: 31176696.

Burgstaller S, Bischof H, Gensch T, Stryeck S, Gottschalk B, Ramadani-Muja J,  Eroglu E, Rost R, Balfanz S, Baumann A, Waldeck-Weiermair M, Hay JC, Madl T, Graier WF, Malli R. pH-Lemon, a Fluorescent Protein-Based pH Reporter for Acidic  Compartments. ACS Sens. 2019 Apr 26;4(4):883-891. doi: 10.1021/acssensors.8b01599. Epub 2019 Mar 30. PubMed PMID: 30864782; PubMed Central PMCID: PMC6488996.

Depaoli MR, Karsten F, Madreiter-Sokolowski CT, Klec C, Gottschalk B, Bischof  H, Eroglu E, Waldeck-Weiermair M, Simmen T, Graier WF, Malli R. Real-Time Imaging of Mitochondrial ATP Dynamics Reveals the Metabolic Setting of Single Cells. Cell Rep. 2018 Oct 9;25(2):501-512.e3. doi: 10.1016/j.celrep.2018.09.027. PubMed PMID: 30304688; PubMed Central PMCID: PMC6456002.

Deak AT, Gottschalk B, Eroglu E, Rost R, Waldeck-Weiermair M, Graier WF, Malli R. High-Resolution Imaging of STIM/Orai Subcellular Localization Using Array Confocal Laser Scanning Microscopy. Methods Mol Biol. 2018;1843:175-187. doi: 10.1007/978-1-4939-8704-7_15. PubMed PMID: 30203287.

Eroglu E, Bischof H, Charoensin S, Waldeck-Weiermaier M, Graier WF, Malli R. Real-Time Imaging of Nitric Oxide Signals in Individual Cells Using geNOps. Methods Mol Biol. 2018;1747:23-34. doi: 10.1007/978-1-4939-7695-9_3. PubMed PMID: 29600448.

Eroglu E, Charoensin S, Bischof H, Ramadani J, Gottschalk B, Depaoli MR, Waldeck-Weiermair M, Graier WF, Malli R. Genetic biosensors for imaging nitric oxide in single cells. Free Radic Biol Med. 2018 Nov 20;128:50-58. doi: 10.1016/j.freeradbiomed.2018.01.027. Epub 2018 Feb 2. Review. PubMed PMID: 29398285; PubMed Central PMCID: PMC6173299.

Opelt M, Wölkart G, Eroglu E, Waldeck-Weiermair M, Malli R, Graier WF, Kollau  A, Fassett JT, Schrammel A, Mayer B, Gorren ACF. Sustained Formation of Nitroglycerin-Derived Nitric Oxide by Aldehyde Dehydrogenase-2 in Vascular Smooth Muscle without Added Reductants: Implications for the Development of Nitrate Tolerance. Mol Pharmacol. 2018 Apr;93(4):335-343. doi: 10.1124/mol.117.110783. Epub 2018 Jan 22. PubMed PMID: 29358221; PubMed Central PMCID: PMC5933520.

Bischof H, Rehberg M, Stryeck S, Artinger K, Eroglu E, Waldeck-Weiermair M, Gottschalk B, Rost R, Deak AT, Niedrist T, Vujic N, Lindermuth H, Prassl R, Pelzmann B, Groschner K, Kratky D, Eller K, Rosenkranz AR, Madl T, Plesnila N, Graier WF, Malli R. Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo. Nat Commun. 2017 Nov 10;8(1):1422. doi: 10.1038/s41467-017-01615-z. PubMed PMID: 29127288; PubMed Central PMCID: PMC5681659.

Eroglu E, Hallström S, Bischof H, Opelt M, Schmidt K, Mayer B, Waldeck-Weiermair M, Graier WF, Malli R. Real-time visualization of distinct nitric oxide generation of nitric oxide synthase isoforms in single cells. Nitric Oxide. 2017 Nov 1;70:59-67. doi: 10.1016/j.niox.2017.09.001. Epub 2017 Sep 4. PubMed PMID: 28882669; PubMed Central PMCID: PMC6002809.

Eroglu E, Rost R, Bischof H, Blass S, Schreilechner A, Gottschalk B, Depaoli  MR, Klec C, Charoensin S, Madreiter-Sokolowski CT, Ramadani J, Waldeck-Weiermair  M, Graier WF, Malli R. Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells. J Vis Exp. 2017 Mar 16;(121). doi: 10.3791/55486. PubMed PMID: 28362417; PubMed Central PMCID: PMC5408997.

Charoensin S, Eroglu E, Opelt M, Bischof H, Madreiter-Sokolowski CT, Kirsch A, Depaoli MR, Frank S, Schrammel A, Mayer B, Waldeck-Weiermair M, Graier WF, Malli R. Intact mitochondrial Ca(2+) uniport is essential for agonist-induced activation of endothelial nitric oxide synthase (eNOS). Free Radic Biol Med. 2017 Jan;102:248-259. doi: 10.1016/j.freeradbiomed.2016.11.049. Epub 2016 Dec 5. PubMed PMID: 27923677; PubMed Central PMCID: PMC5381715.

Opelt M, Eroglu E, Waldeck-Weiermair M, Russwurm M, Koesling D, Malli R, Graier WF, Fassett JT, Schrammel A, Mayer B. Formation of Nitric Oxide by Aldehyde Dehydrogenase-2 Is Necessary and Sufficient for Vascular Bioactivation of Nitroglycerin. J Biol Chem. 2016 Nov 11;291(46):24076-24084. Epub 2016 Sep 27. PubMed PMID: 27679490; PubMed Central PMCID: PMC5104933.

Madreiter-Sokolowski CT, Gottschalk B, Parichatikanond W, Eroglu E, Klec C, Waldeck-Weiermair M, Malli R, Graier WF. Resveratrol Specifically Kills Cancer Cells by a Devastating Increase in the Ca2+ Coupling Between the Greatly Tethered Endoplasmic Reticulum and Mitochondria. Cell Physiol Biochem. 2016;39(4):1404-20. doi: 10.1159/000447844. Epub 2016 Sep 9. PubMed PMID: 27606689; PubMed Central PMCID: PMC5382978.

Madreiter-Sokolowski CT, Klec C, Parichatikanond W, Stryeck S, Gottschalk B,  Pulido S, Rost R, Eroglu E, Hofmann NA, Bondarenko AI, Madl T, Waldeck-Weiermair  M, Malli R, Graier WF. PRMT1-mediated methylation of MICU1 determines the UCP2/3  dependency of mitochondrial Ca(2+) uptake in immortalized cells. Nat Commun. 2016 Sep 19;7:12897. doi: 10.1038/ncomms12897. PubMed PMID: 27642082; PubMed Central PMCID: PMC5031806.

Malli R, Eroglu E, Waldeck-Weiermair M, Graier WF. Filling a GAP-An Optimized Probe for ER Ca(2+) Imaging In Vivo. Cell Chem Biol. 2016 Jun 23;23(6):641-3. doi: 10.1016/j.chembiol.2016.06.003. PubMed PMID: 27341431.

Eroglu E, Gottschalk B, Charoensin S, Blass S, Bischof H, Rost R, Madreiter-Sokolowski CT, Pelzmann B, Bernhart E, Sattler W, Hallström S, Malinski T, Waldeck-Weiermair M, Graier WF, Malli R. Development of novel FP-based probes  for live-cell imaging of nitric oxide dynamics. Nat Commun. 2016 Feb 4;7:10623. doi: 10.1038/ncomms10623. PubMed PMID: 26842907; PubMed Central PMCID: PMC4743004.

Waldeck-Weiermair M, Bischof H, Blass S, Deak AT, Klec C, Graier T, Roller C, Rost R, Eroglu E, Gottschalk B, Hofmann NA, Graier WF, Malli R. Generation of Red-Shifted Cameleons for Imaging Ca²⁺ Dynamics of the Endoplasmic Reticulum. Sensors (Basel). 2015 Jun 4;15(6):13052-68. doi: 10.3390/s150613052. PubMed PMID: 26053751; PubMed Central PMCID: PMC4507692.