Ozlem Kutlu
E-mail : ozlem.kutlu
sabanciuniv.edu
Areas of Interest :
Molecular Mechanism of Rare Human Genetic Disease, Molecular Cell Death Mechanism of Human Diseases (Cancer, Alzheimer, Parkinson etc.) Drug Delivery Research with Biodegradable Nanoparticles, Biomedical Applications of Medical Devices.Awards :
- 3rd Oral Best Presentation - V.International Lysosomal Storage Disease Congress 2016
- Technology Award - Elginkan Foundation 2015
- Sabanci University Post-doctoral fellowship - Sabanci University, Nanotechnology Research and Application Center 2012
- Sabanci University Post-doctoral fellowship - Sabanci University, Faculty of Engineering and Natural Science 2011
- TÜBİTAK Post-doctoral fellowship - Sabanci University 2009
- Japanese Government Scholarship for PhD - Kumamoto University 2005
- Japanese Government Scholarship for MSc. - Kumamoto University 2003
- Turkish Government Higher Education Fellowship - Ege University 1997
Membership :
Member of the International Cell Death Society (ICDS) Member of the European Cell Death Organization (ECDO) Member of the Molecular Biology Society of Japan (MBSJ)Publications :
| Article |
| Çimen, Atike Nur and Çelebi Torabfam, Gizem and Tok, Yesim Tuyji and Yucebag, Ebru and Arslan, Neşe and Saribal, Devrim and Esken, Gülen and Dogan, Özlem and Kuskucu, Mert Ahmet and Mete, Bilgul and Aygun, Gokhan and Tabak, Fehmi and Can, Füsun and Ergonul, Onder and Midilli, Kenan and Kutlu, Özlem and Çetinel, Sibel (2024) "Development of pseudotyped VSV-SARS-CoV-2 spike variants for the assessment of neutralizing antibodies", Bioanalysis, Vol.16, No.21-22, 1167-1177 (SCI) |
| Durak, Saliha and Şutova, Hande Eda and Ceylan, Ramazan and Açıksarı, Ayşegül and Yetişgin, Abuzer Alp and Onder Tokuc, Ecem and Kutlu, Özlem and Karabas, Veysel Levent and Çetinel, Sibel (2024) "A nanogel formulation of anti-VEGF peptide for ocular neovascularization treatment". Published Online First https://dx.doi.org/10.1021/acsabm.4c00585 |
| Yetişgin, Abuzer Alp and Durak, Saliha and Kutlu, Özlem and Çetinel, Sibel (2024) "Hyaluronan-sphingosine polymersomes for treatment of ocular neovascularization: synthesis and evaluation", Macromolecular Bioscience, Vol.24, No.6 (SCI) |
| Namlı, İlayda and Karavelioglu, Zeynep and Seyedmirzaei Sarraf, Seyedali and Sheibani Aghdam, Araz and Varol, Rahmetullah and Yilmaz, Abdurrahim and Şahin, Sevilay Burcu and Özogul, Beyzanur and Bozkaya, Dila Naz and Acar, Havva Funda and Uvet, Huseyin and Çetinel, Sibel and Kutlu, Özlem and Ghorbani, Morteza and Koşar, Ali (2023) "On the application of hydrodynamic cavitation on a chip in cellular injury and drug delivery", Lab On a Chip, Vol.23, No.11, 2640-2653 (SCI) |
| Çelebi Torabfam, Gizem and Yetişgin, Abuzer Alp and Erdem, Cem and Çaylı, Aziz and Kutlu, Özlem and Çetinel, Sibel (2022) "A feasibility study of different commercially available serum-free mediums to enhance lentivirus and adeno-associated virus production in HEK 293 suspension cells", Cytotechnology, Vol.74, No.6, 635-655 (SCI) |
| Egil, Abdurrahim Can and Kesim, Hale and Üstünkaya, Beril and Kutlu, Özlem and Özaydın İnce, Gözde (2022) "Self-assembled albumin nanoparticles for redox responsive release of curcumin", Journal of Drug Delivery Science and Technology, Vol.76 (SCI) |
| Namlı, İlayda and Seyedmirzaei Sarraf, Seyedali and Sheibani Aghdam, Araz and Çelebi Torabfam, Gizem and Kutlu, Özlem and Çetinel, Sibel and Ghorbani, Morteza and Koşar, Ali (2022) "Hydrodynamic cavitation on a chip: a tool to detect circulating tumor cells", ACS Applied Materials and Interfaces, Vol.14, No.36, 40688-40697 (SCI) |
| Abbasiasl, Taher and Şutova, Hande Eda and Niazi, Soroush and Çelebi Torabfam, Gizem and Karavelioglu, Zeynep and Kirabali, Ufuk and Yilmaz, Abdurrahim and Uvet, Huseyin and Kutlu, Özlem and Ekici, Sinan and Ghorbani, Morteza and Koşar, Ali (2022) "A flexible cystoscope based on hydrodynamic cavitation for tumor tissue ablation", IEEE Transactions on Biomedical Engineering, Vol.69, No.1, 513-524 (SCI) |
| Akkiz, Hikmet and Taskin, Emre and Karaogullarindan, Umit and Delik, Anil and Kuran, Sedef and Kutlu, Özlem (2021) "The influence of RS738409 I148M polymorphism of patatin-like phospholipase domain containing 3 gene on the susceptibility of non-alcoholic fatty liver disease", Medicine, Vol.100, No.19 (SCI) |
| Ashrafizadeh, Milad and Kutlu, Özlem (2021) "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)", Autophagy, Vol.17, No.1, 1-382 (SCI) |
| Talebian Gevari, Moein and Aydemir, Gizem and Gharıb, Ghazaleh and Kutlu, Özlem and Uvet, Huseyin and Ghorbani, Morteza and Koşar, Ali (2021) "Local carpet bombardment of immobilized cancer cells with hydrodynamic cavitation", IEEE Access, Vol.9, 14983-14991 (SCI) |
| Çelebi Torabfam, Gizem and Kesim, Hale and Özer, Ebru and Kutlu, Özlem (2020) "The effect of dysfunctional ubiquitin enzymes in the pathogenesis of most common diseases", International Journal of Molecular Sciences, Vol.21, No.17 (SCI) |
| Durak, Saliha and Esmaeili Rad, Monireh and Yetişgin, Abuzer Alp and Şutova, Hande Eda and Kutlu, Özlem and Çetinel, Sibel and Zarrabi, Ali (2020) "Niosomal drug delivery systems for ocular disease-recent advances and future prospects", Nanomaterials, Vol.10, No.6 (SCI) |
| Yetişgin, Abuzer Alp and Çetinel, Sibel and Zuvin, Merve and Koşar, Ali and Kutlu, Özlem (2020) "Therapeutic nanoparticles and their targeted delivery applications", Molecules, Vol.25, No.9 (SCI) |
| Kaleli, Hümeyra Nur and Özer, Ebru and Kaya, Veysel Oğulcan and Kutlu, Özlem (2020) "Protein kinase C isozymes and autophagy during neurodegenerative disease progression", Cells, Vol.9, No.3 (SCI) |
| Zuvin, Merve and Koçak, Muhammed and Ünal, Özlem and Akkoç, Yunus and Kutlu, Özlem and Yağcı Acar, Havva and Gözüaçık, Devrim and Koşar, Ali (2019) "Nanoparticle based induction heating at low magnitudes of magnetic field strengths for breast cancer therapy", Journal of Magnetism and Magnetic Materials, Vol.483, 169-177 (SCI) |
| Zuvin, Merve and Kuruoğlu, Efe and Kaya, Veysel Oğulcan and Ünal, Özlem and Kutlu, Özlem and Yağcı Acar, Havva and Gözüaçık, Devrim and Koşar, Ali (2019) "Magnetofection of green fluorescent protein encoding DNA-bearing polyethyleneimine-coated superparamagnetic iron oxide nanoparticles to human breast cancer cells", ACS Omega, Vol.4, No.7, 12366-12374 (SCI) |
| Kocatürk, Nur Mehpare and Akkoç, Yunus and Kığ, Cenk and Bayraktar, Öznur and Gözüaçık, Devrim and Kutlu, Özlem (2019) "Autophagy as a molecular target for cancer treatment", European Journal of Pharmaceutical Sciences, Vol.134, 116-137 (SCI) |
| Aydoğdu, Mehmet Onur and Chou, Joshua and Altun, Esra and Ekren, Nazmi and Çakmak, Selami and Eroğlu, Mehmet and Osman, Asıla A. and Kutlu, Özlem and Toksoy Öner, Ebru and Avşar, Gülben and Oktar, Faik Nüzhet and Yılmaz, İsmail and Gündüz, Oğuzhan (2019) "Production of the biomimetic small diameter blood vessels for cardiovascular tissue engineering", International Journal of Polymeric Materials and Polymeric Biomaterials, Vol.68, No.5, 243-255 (SCI) |
| Özbey, Arzu and Karimzadehkhouei, Mehrdad and Kocatürk, Nur Mehpare and Erbil Bilir, Seçil and Kutlu, Özlem and Gözüaçık, Devrim and Koşar, Ali (2019) "Inertial focusing of cancer cell lines in curvilinear microchannels", Micro and Nano Engineering, Vol.2, 53-63 (ESCI) |
| Önal, Gizem and Kutlu, Özlem and Özer, Ebru and Gözüaçık, Devrim and Karaduman, Ayşen and Dökmeci Emre, Serap (2019) "Impairment of lipophagy by PNPLA1 mutations causes lipid droplet accumulation in primary fibroblasts of autosomal recessive congenital ichthyosis patients", Journal of Dermatological Science, Vol.93, No.1, 50-57 (SCI) |
| Altun, Esra and Aydoğdu, Mehmet Onur and Koç, Fatma and Kutlu, Özlem and Gözüaçık, Devrim and Yücel, Sevil and Gündüz, Oğuzhan (2018) "Amoxicillin loaded hollow microparticles in the treatment of osteomyelitis disease using single-nozzle electrospinning", BioNanoScience, Vol.8, No.3, 790-801 (ESCI) |
| Kutlu, Özlem and Kaleli, Hümeyra Nur and Özer, Ebru (2018) "Molecular pathogenesis of nonalcoholic steatohepatitis- (NASH-) related hepatocellular carcinoma", Canadian Journal of Gastroenterology and Hepatology, Vol.2018 (SCI) |
| Unal, Semra and Ekren, Nazmi and Sengil, Ahmet Z. and Oktar, Faik N. and Irmak, Ster and Kutlu, Özlem and Sahin, Yesim M. and Kilic, Osman and Agathopoulos, Simeon and Gunduz, Oguzhan (2018) "Synthesis, characterization, and biological properties of composites of hydroxyapatite and hexagonal boron nitride", Journal of Biomedical Materials Research - Part B Applied Biomaterials, Vol.106, No.6, 2384-2392 (SCI) |
| Önal, Gizem and Kutlu, Özlem and Gözüaçık, Devrim and Dökmeci Emre, Serap (2017) "Lipid droplets in health and disease", Lipids in Health and Disease, Vol.16 (SCI) |
| Kutlu Oral, Özlem and Yedier, Özlem and Kılıç, Seval and Gözüaçık, Devrim (2017) "Involvement of autophagy in T cell biology", Histology and Histopathology, Vol.32, No.1, 11-20 (SCI) |
| Bayraktar, Öznur and Oral, Özlem and Kocatürk, Nur Mehpare and Akkoç, Yunus and Eberhart, Karin and Koşar, Ali and Gözüaçık, Devrim (2016) "IBMPFD disease-causing mutant VCP/p97 proteins are targets of autophagic-lysosomal degradation", PLoS One, Vol.11, No.10 (SCI) |
| Oral, Özlem and Kılıç, Seval and Yedier, Özlem and Dökmeci, Serap and Gözüaçık, Devrim (2016) "Effect of serine/threonine kinases on autophagy mechanism", International Journal of Biomedical and Biological Engineering, Vol.3, No.10 (NA) |
| Oral, Özlem and Taşkın, Emre and Yüce, Aysel and Dökmeci, Serap and Gözüaçık, Devrim (2016) "Significance of molecular autophagic pathway in Gaucher disease pathology", International Journal of Biomedical and Biological Engineering, Vol.3, No.10 (NA) |
| Erbil, Seçil and Oral, Özlem and Mitou, Geraldine and Kığ, Cenk and Durmaz, Emel and Güven-Maiorov, Emine and Gülaçtı, Ferah and Gökçe, Gökçen and Dengjel, Jön and Sezerman, Uğur and Gözüaçık, Devrim (2016) "RACK1 is an interaction partner of ATG5 and a novel regulator of autophagy", Journal of Biological Chemistry, Vol.291, No.32, 16753-16765 (SCI) |
| Ghorbani, Morteza and Oral, Özlem and Ekici, Sinan and Gözüaçık, Devrim and Koşar, Ali (2016) "Review on lithotripsy and cavitation in urinary stone therapy", IEEE Reviews in Biomedical Engineering, Vol.9, 264-283 (NA) |
| Oral, Özlem and Akkoç, Yunus and Bayraktar, Öznur and Gözüaçık, Devrim (2016) "Physiological and pathological significance of the molecular cross-talk between autophagy and apoptosis", Histology and Histopathology, Vol.31, No.5, 479-498 (SCI) |
| Oral, Özlem and Çıkım, Taha Abdullah and Zuvin, Merve and Ünal, Özlem and Yağcı-Acar, Havva and Gözüaçık, Devrim and Koşar, Ali (2015) "Effect of varying magnetic fields on targeted gene delivery of nucleic acid-based molecules", Annals of Biomedical Engineering, Vol.43, No.11, 2816-2826 (SCI) |
| Üzüşen, Doğan and Demir, Ebru and Perk, Osman Yavuz and Oral, Özlem and Ekici, Sinan and Ünel, Mustafa and Gözüaçık, Devrim and Koşar, Ali (2015) "Assessment of probe-to-specimen distance effect in kidney stone treatment with hydrodynamic cavitation", Journal of Medical Devices, Vol.9, No.3 (SCI) |
| İtah, Zeynep and Oral, Özlem and Perk, Osman Yavuz and Şeşen, Muhsincan and Demir, Ebru and Erbil, Seçil and Doğan-Ekici, A. Işın and Ekici, Sinan and Koşar, Ali and Gözüaçık, Devrim (2013) "Hydrodynamic cavitation kills prostate cells and ablates benign prostatic hyperplasia tissue", Experimental Biology and Medicine, Vol.238, No.11, 1-9 (SCI) |
| Oral, Özlem and Öz-Arslan, Devrim and İtah, Zeynep and Naghavi, Atabak and Deveci, Remziye and Karaçalı, Sabire and Gözüaçık, Devrim (2012) "Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death", Apoptosis, Vol.17, No.8, 810-820 (SCI) |
| Koşar, Ali and Şeşen, Muhsincan and Oral, Özlem and İtah, Zeynep and Gözüaçık, Devrim (2011) "Bubbly cavitating flow generation and investigation of its erosional nature for biomedical applications", IEEE Transactions on Biomedical Engineering, Vol.58, No.5, 1337-1346 (SCI) |
| Book Section / Chapter |
| Durak, Saliha and Şutova, Hande Eda and Yetişgin, Abuzer Alp and Kutlu, Özlem and Çetinel, Sibel, "Potency of SARS-CoV-2 on ocular tissues", Infectious Eye Diseases - Recent Advances in Diagnosis and Treatment, Rodriguez-Garcia, Alejandro and Hernandez-Camarena, Julio C. (eds.), United Kingdom: Intechopen, October 2021 |
| Ben Taleb, Ali and Karakuş, Selcan and Tan, Ezgi and Ilgar, Merve and Kutlu, Özlem and Gözüaçık, Devrim and Kutlu, Hatice Mehtap and Kilislioğlu, Ayben, "Antitumor efficacy of ceranib-2 with nano-formulation of PEG and rosin esters", Supramolecules in Drug Discovery and Drug Delivery: Methods and Protocols, Mavromoustakos, Thomas and Tzakos, Andreas G. and Durdagi, Serdar (eds.), New York, NY: Humana Press, January 2021, 199-220 |
| Erbil Bilir, Seçil and Gözüaçık, Devrim and Kutlu, Özlem, "Autophagy as a physiological response of the body to starvation", Handbook of Famine, Starvation, and Nutrient Deprivation: From Biology to Policy, Preedy, Victor R. and Patel, Vinood B. (eds.), United Kingdom: Springer Cham, March 2019, 2067-2081 |
| Eberhart, Karin and Oral, Özlem and Gözüaçık, Devrim, "Induction of autophagic cell death by anticancer agents", Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, and Infection, and Aging, Hayat, M. A. (ed.), The Netherlands: Elsevier, October 2013, 179-202 |
| Oral, Özlem and Irmak, Ster and Ekici, Sinan and Gözüaçık, Devrim, "Autophagy in urology (Ürolojide otofaji)", Moleküler Üroloji, Türkeri, Levent and Özer, Ayşe and Narter, Fehmi (eds.), İstanbul: Üroonkoloji Derneği Yayınları, November 2012, 271-283 |
| Papers in Conference Proceedings |
| Kaya, Veysel Oğulcan and Kutlu, Özlem and Koşar, Ali, "Enhancing the efficiency of electronic cooling devices by bio-coatings", IEEE International Conference on Microwaves, Antennas, Communications and Electronic Systems (COMCAS), Institute of Electrical and Electronics Engineers, November 2019 |
| Kılıç, Seval and Yedier, Özlem and Gözüaçık, Devrim and Kutlu, Özlem, "Identification of a serine-threonine kinase as a novel autophagic regulator", VI. International Congress of Molecular Medicine, TJMBB, May 2017, 113-113 |
| Yedier, Özlem and Kılıç, Seval and Gözüaçık, Devrim and Kutlu, Özlem, "PMA functions as an autophagy inhibitor through activation of a serine threonine kinase", VI. International Congress of Molecular Medicine, TJMBB, May 2017, 122-123 |
| Oral, Özlem and Sarafi, Parisa and Yüce, Aysel and Gözüaçık, Devrim and Dökmeci, Serap, "Molecular mechanism of autophagic pathway in Gaucher cells", SSIEM Annual Symposium 2016, SSIEM, September 2016 |
| Oral, Özlem and Bayraktar, Öznur and Yücel, Aysel and Dökmeci, Serap and Gözüaçık, Devrim, "Molecular significance of autophagy in Gaucher disease", 1st International Cell Death Research Congress, Cell Death Research Society, May 2016 |
| Oral, Özlem and Demir, Hülya and Yüce, Aysel and Gözüaçık, Devrim and Dökmeci Emre, Serap, "Gaucher hastalığı patolojisinde otofaji moleküler mekanizması", V.Uluslararası Katılımlı Lizozomal Hastalıklar Kongresi, Çocuk Beslenme ve Metabolizma Derneği, April 2016 |
| Oral, Özlem and Yüce, Aysel and Dökmeci, Serap and Gözüaçık, Devrim, "Involvement of autophagy abnormalities in Gaucher lysosomal storage disease", ICDS (International Cell Death Society Presents): Implementation of the Knowledge of Cell Death, International Cell Death Society, May 2015 |
| Üzüşen, Doğan and Oral, Özlem and Ekici, Sinan and Ünel, Mustafa and Gözüaçık, Devrim and Koşar, Ali, "Assessment of probe-to-specimen distance effect in kidney stone treatment with hydrodynamic cavitation", 4th European Conference on Microfluidics (Microfluidics 2014), Limerick, Ireland: University of Limerick, December 2014 |
| Çıkım, Taha Abdullah and Oral, Özlem and Acar, Havva Funda Yagci and Gözüaçık, Devrim and Koşar, Ali, "Effect of varying magnetic fields on targeted gene delivery of nucleic acid-based molecules", 4th Micro and Nano Flows Conference (MNF2014), London, UK: University of City College London, October 2014 |
| Oral, Özlem and Sarafi, Parisa and Yüce, Aysel and Dökmeci, Serap and Gözüaçık, Devrim, "Autophagy abnormalities in mutant cells isolated from Gaucher's lysosomal storage disease", FEBS Advanced Lecture Course 360° Lysosome: from Structure to Genomics, from Function to Disease, FEBS (Federation of European Biochemical Societies), October 2014 |
| Oral, Özlem and Sarafi, Parisa and Yüce, Aysel and Gözüaçık, Devrim and Dökmeci, Serap, "Molecular and cellular analysis of autophagy in Gaucher disease (Gaucher hastalığında, otofaji mekanizması ve aktivitesinin moleküler ve hücresel düzeyde incelenmesi)", XIII. Ulusal Tıbbi Biyoloji ve Genetik Kongresi, Tıbbi Biyoloji Derneği, October 2013 |
| Koşar, Ali and Akbaş, Akın and Şahin, Ö. and Kubilay, Aytaç and Oral, Özlem and Gözüaçık, Devrim, "Bubbly cavitating flow generation and investigation of its erosional nature for biomedical applications", 2nd Micro and Nano Flows Conference, West London, UK: MNF2009, September 2009 |
Before SU Publications:
Oral O., Uchida I., Eto K., Nakayama Y., Nishimura O., Hirao Y., Ueda J., Tarui H., Agata K., Abe S-I (2008) Promotion of spermatogonial proliferation by Neuregulin-1 in newt (Cynops pyrrhogaster) testis, Mech Dev. 125, 906-917
Yuwen Li, Ozlem Oral, Keisuke Abe, Ko Eto, Shin-ichi Abe (2008) The roles of pericystic cells and sertoli cells in spermatogonial proliferation stimulated by some growth factors in organ culture of newt (Cynops pyrrhogaster) testis, Gen. Comp. Endoc. 159, 80-87