Duygu Kuzuoğlu Öztürk

E-posta : duygu.kuzuoglusabanciuniv.edu

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Article

Kuzuoğlu Öztürk, Duygu and Nguyen, Hao G. and Xue, Lingru and Figueredo, Emma and Subramanyam, Vishvak and Liu, Isabelle and Bonitto, Kenya and Noronha, Ashish and Dabrowska, Adrianna and Cowan, Janet E. and Oses-Prieto, Juan A. and Burlingame, Alma L. and Worland, Stephen T. and Carroll, Peter R. and Ruggero, Davide (2025) "Small-molecule RNA therapeutics to target prostate cancer", Cancer Cell, Vol.43, No.5, 841-855 (SCI)

SU Öncesi Yayınları:

· Kuzuoglu-Ozturk D*, Nguyen HG*, Xue L, Figueredo E, Subramanyam V, Liu I, Bonitto K, Noronha A, Dabrowska A, Cowan JE, Oses-Prieto JA, Burlingame A, Worland ST, Carroll PR, Ruggero D. Small molecule RNA therapeutics to target prostate cancer. (2025) Cancer Cell

· Chesner L et al, including Kuzuoglu-Ozturk D. AR inhibition increases MHC Class I expression and improves immune response in prostate cancer (2025) Cancer Discovery 15 (3): 481-494

· Zhulyn O, Rosenblatt HD, Shokat L, Dai S, Kuzuoglu-Ozturk D, Zhang Z, Ruggero D, Shokat KM, Barna M. Evolutionarily divergent mTOR remodels translatome for tissue regeneration (2023) Nature, 620(7972): 163-171.

· Kuzuoglu-Ozturk D. PHGDH and cancer: new job for an old enzyme! (2023) EMBO J, 42(3):e113068.

· Kuzuoglu-Ozturk D*, Aksoy O*, Schmidt C, Lea R, Larson JD, Phelps RRL, Nasholm N, Holt M, Contreras A, Huang M, Michalak S, Shao H, Wechsler-Reya R, Phillips J, Gestwicki J, Ruggero D#, Weiss WA#. The MYCN-driven translatome reveals translational control of protein folding machinery as a vulnerability in medulloblastoma. (2023) Cancer Res, 83 (1):1300-140.

· Kovalski J* #, Kuzuoglu-Ozturk D* # and Ruggero D#. Protein Synthesis Control in Cancer: Selectivity and Therapeutic Targeting (2022) EMBO J. 41:e109823.

· Liedmann S, Liu X, Guy CS, Crawford JC, Rodriguez DA, Kuzuoglu-Ozturk D, Guo A, Temirov J, Chen MJ, Ruggero D, Zhang H, Thomas PG, Green DR. Localized translation of c-Myc drives divergent cell fate in CD8+ T cells (2022) Mol Cell, 82(13): 2401-2414.

· Kuzuoglu-Ozturk D, Hu Z, Rama M, Devericks E, Weiss J, Chiang GG, Worland ST, Brenner SE, Goodarzi H, Gilbert LA and Ruggero D (2021) Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome. Cell Reports 35: 109321.

· Gordon D et al. including Kuzuoglu-Ozturk D (2020) A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature 583, 459–468.

· Hanet A, Räsch F, Weber R, Ruscica V, Fauser M, Raisch T, Kuzuoglu-Ozturk D, Chang CT, Bhandari D, Igreja C, Wohlbold L. (2019) HELZ directly interacts with CCR4-NOT and causes decay of bound mRNAs. Life Sci Alliance 2(5).

· Sgromo A, Raisch T, Bawankar P, Bhandari D, Chen Y, Kuzuoglu-Ozturk D, Weichenrieder O & Izaurralde E (2017) A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin. Nat Commun 8:14307.

· Kuzuoglu-Ozturk D, Bhandari D, Huntzinger E, Fauser M, Helms S, & Izaurralde E (2016) miRISC and the CCR4-NOT complex repress and degrade mRNA targets independently of 43S ribosomal scanning. EMBO J 35, 1186-203.

· Chen Y*, Boland A*, Kuzuoglu-Ozturk D*, Bawankar P, Loh B, Chang CT, Weichenrieder O & Izaurralde E (2014) A DDX6-CNOT1 Complex and W-Binding Pockets in CNOT9 Reveal Direct Links between miRNA Target Recognition and Silencing. Mol Cell 54, 737-50.

· Boland* A, Chen* Y, Raisch* T, Jonas* S, Kuzuoglu-Ozturk D, Wohlbold L, Weichenrieder O & Izaurralde E (2013) Structure and assembly of the NOT module of the human CCR4-NOT complex. Nat Struct Mol Biol 20, 1289-97.

· Zekri L, Kuzuoglu-Ozturk D & Izaurralde E (2013) GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation. EMBO J 32, 1052-65.

· Huntzinger* E, Kuzuoglu-Ozturk* D, Braun JE, Eulalio A, Wohlbold L & Izaurralde E (2013) The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets. Nucleic Acids Res 41, 978-94.

· Kuzuoglu-Ozturk D, Huntzinger E, Schmidt S & Izaurralde E (2012) The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes. Nucleic Acids Res 40, 5651-65.

· Kuzuoglu-Ozturk D*, Cebeci Yalcinkaya O*, Akpinar BA, Mitou G, Korkmaz G, Gozuacik D & Budak H (2012) Autophagy-related gene, TdAtg8, in wild emmer wheat plays a role in drought and osmotic stress response. Planta. 236, 1081-92.

· Seyahi E, Tahir Turanli E, Mangan MS, Celikyapi G, Oktay V, Cevirgen D, Kuzuoglu D, Ozoglu S & Yazici H (2010) The prevalence of Behcet's syndrome, familial Mediterranean fever, HLA-B51 and MEFV gene mutations among ethnic Armenians living in Istanbul, Turkey.Clin Exp Rheumatol 28, S67-75.

*Equal contribution

#Co-corresponding