English version

Duygu Kuzuoğlu Öztürk

E-posta : duygu.kuzuoglusabanciuniv.edu

·       Kuzuoglu-Ozturk D*, Nguyen HG*, Xue L, Figueredo E, Subramanyam V, Liu I, Bonitto K, Noronha A, Dabrowska A, Cowan JE, Oses-Prieto JA, Burlingame A, Worland ST, Carroll PR, Ruggero D. Small molecule RNA therapeutics to target prostate cancer. (2025) Cancer Cell

·       Chesner L et al, including Kuzuoglu-Ozturk D. AR inhibition increases MHC Class I expression and improves immune response in prostate cancer (2025) Cancer Discovery 15 (3): 481-494

·       Zhulyn O, Rosenblatt HD, Shokat L, Dai S, Kuzuoglu-Ozturk D, Zhang Z, Ruggero D, Shokat KM, Barna M. Evolutionarily divergent mTOR remodels translatome for tissue regeneration (2023) Nature, 620(7972): 163-171.

·       Kuzuoglu-Ozturk D. PHGDH and cancer: new job for an old enzyme! (2023) EMBO J, 42(3):e113068.

·       Kuzuoglu-Ozturk D*, Aksoy O*, Schmidt C, Lea R, Larson JD, Phelps RRL, Nasholm N, Holt M, Contreras A, Huang M, Michalak S, Shao H, Wechsler-Reya R, Phillips J, Gestwicki J, Ruggero D#, Weiss WA#. The MYCN-driven translatome reveals translational control of protein folding machinery as a vulnerability in medulloblastoma. (2023) Cancer Res, 83 (1):1300-140.

·       Kovalski J* #, Kuzuoglu-Ozturk D* # and Ruggero D#. Protein Synthesis Control in Cancer: Selectivity and Therapeutic Targeting (2022) EMBO J. 41:e109823.

·       Liedmann S, Liu X, Guy CS, Crawford JC, Rodriguez DA, Kuzuoglu-Ozturk D, Guo A, Temirov J, Chen MJ, Ruggero D, Zhang H, Thomas PG, Green DR. Localized translation of c-Myc drives divergent cell fate in CD8+ T cells (2022) Mol Cell, 82(13): 2401-2414.

·       Kuzuoglu-Ozturk D, Hu Z, Rama M, Devericks E, Weiss J, Chiang GG, Worland ST, Brenner SE, Goodarzi H, Gilbert LA and Ruggero D (2021) Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome. Cell Reports 35: 109321.

·       Gordon D et al. including Kuzuoglu-Ozturk D (2020) A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature 583, 459–468.

·       Hanet A, Räsch F, Weber R, Ruscica V, Fauser M, Raisch T, Kuzuoglu-Ozturk D, Chang CT, Bhandari D, Igreja C, Wohlbold L. (2019) HELZ directly interacts with CCR4-NOT and causes decay of bound mRNAs. Life Sci Alliance 2(5).

·       Sgromo A, Raisch T, Bawankar P, Bhandari D, Chen Y, Kuzuoglu-Ozturk D, Weichenrieder O & Izaurralde E (2017) A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin. Nat Commun 8:14307.

·       Kuzuoglu-Ozturk D, Bhandari D, Huntzinger E, Fauser M, Helms S, & Izaurralde E (2016) miRISC and the CCR4-NOT complex repress and degrade mRNA targets independently of 43S ribosomal scanning. EMBO J 35, 1186-203.

·       Chen Y*, Boland A*, Kuzuoglu-Ozturk D*, Bawankar P, Loh B, Chang CT, Weichenrieder O & Izaurralde E (2014) A DDX6-CNOT1 Complex and W-Binding Pockets in CNOT9 Reveal Direct Links between miRNA Target Recognition and Silencing. Mol Cell 54, 737-50.

·       Boland* A, Chen* Y, Raisch* T, Jonas* S, Kuzuoglu-Ozturk D, Wohlbold L, Weichenrieder O & Izaurralde E (2013) Structure and assembly of the NOT module of the human CCR4-NOT complex. Nat Struct Mol Biol 20, 1289-97.

·       Zekri L, Kuzuoglu-Ozturk D & Izaurralde E (2013) GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation. EMBO J 32, 1052-65.

·       Huntzinger* E, Kuzuoglu-Ozturk* D, Braun JE, Eulalio A, Wohlbold L & Izaurralde E (2013) The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets. Nucleic Acids Res 41, 978-94.

·       Kuzuoglu-Ozturk D, Huntzinger E, Schmidt S & Izaurralde E (2012) The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes. Nucleic Acids Res 40, 5651-65. 

·       Kuzuoglu-Ozturk D*, Cebeci Yalcinkaya O*, Akpinar BA, Mitou G, Korkmaz G, Gozuacik D & Budak H (2012) Autophagy-related gene, TdAtg8, in wild emmer wheat plays a role in drought and osmotic stress response. Planta. 236, 1081-92.

·       Seyahi E, Tahir Turanli E, Mangan MS, Celikyapi G, Oktay V, Cevirgen D, Kuzuoglu D, Ozoglu S & Yazici H (2010) The prevalence of Behcet's syndrome, familial Mediterranean fever, HLA-B51 and MEFV gene mutations among ethnic Armenians living in Istanbul, Turkey.Clin Exp Rheumatol 28, S67-75.

*Equal contribution

#Co-corresponding