The digital transformation that has been happening in the industry is leading to the disappearance of borders between cyber and physical systems and creating synergies between them. In order to maintain and improve their firms’ competitiveness, decision makers need to know the technologies, approaches, and best practices that further this transformation. Digital transformation has also helped recognition of the role of innovation in global competitive environment among other operational priorities (cost, quality, flexibility, and delivery). This course, involve an in -depth discussion into such topics, cases, and best practices.