This course will introduce advanced design and fabrication methodologies in development of customized medical devices and tools, implants, and engineered tissues, organs and biological systems. The topics covered include computer- aided design and representation of biological objects, computational geometry for medical imaging and processing, reverse engineering, computer-aided analysis and engineering, biomaterials, tissue engineering, additive manufacturing for biomedical engineering applications, bio- manufacturing and manufacturing processes for medical devices/tools. The course also includes several related hands-on laboratory projects.