Devrim  Gozuacık

Türkçe sürüm

Devrim Gozuacık

E-mail : dgozuaciksabanciuniv.edu

Personal web page

Education :

PhD, Molecular and Cell Biology, Pasteur Institute, Paris, 2001.
MD, Hacettepe Faculty of Medicine, 1995.

Work Experience :

2006-today, Lab Head and Faculty Member, Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul. 
2001-2006, Postdoctoral fellow, Department of Molecular Genetics, Weizmann Institute of Science, Rehovot. 
1995-1996, Part-time researcher, TUBITAK DNA and Cell Bank of Genetic Diseases, Hacettepe Children's Hospital, Ankara.

Areas of Interest :

Molecular medicine, molecular and cell biology, cellular stress and death mechanisms, apoptosis, autophagy, innovative drug research, nanotechnology in medical research.

Awards :

  • Associate Editor - Autophagy journal  2016
  • Board member - International Cell Death Society (ICDS)  2016
  • Board member - Cell Death Research Association of Turkey  2016
  • Board member - International Cell Death Society (ICDS)  2015
  • Elginkan Foundation Technology Award - Elginkan Foundation  2015
  • Editor - Autophagy journal  2014
  • Editor - Turkish Journal of Biology  2014
  • Guest Associate Editor - Turkish Journal of Biology  2014
  • İKÜ Prof Önder Öztunalı Science Award - İKÜ  2014
  • Sedat Simavi Health Sciences Award - Turkish Press Association  2014
  • Editor - Autophagy journal  2011
  • Board of Directors Member - International Cell Death Society (ICDS)  2010
  • TUBA Outstanding Young PI Award. - Turkish Academy of Sciences (TUBA)  2008
  • European Molecular Biology Organization (EMBO) Installation Award - European Molecular Biology Organization  2006

Membership :

EMBO Young Investigator Programme, Inproteolys European Network, International Cell Death Society (ICDS, European Cell Death Organization (ECDO), European Association for Cancer Research (EACR), European Microscopy Society(EMS), Turkish Molecular Biology Association, Turkish Electron Microscopy Association, HÖAD, MOKAD, Society for Experimental Biology and Medicine (SEBM).

Publications :

Article
Gözüaçık, Devrim and Akkoç, Yunus and Öztürk, Deniz Gülfem and Koçak, Muhammed and Agostinis, Patrizia (2017) "Autophagy-Regulating microRNAs and cancer", Frontiers in Oncology, Vol.7 ()
Bayraktar, Öznur and Oral, Özlem and Kocatürk, Nur Mehpare and Akkoç, Yunus and Eberhart, Karin and Koşar, Ali and Gözüaçık, Devrim (2016) "IBMPFD disease-causing mutant VCP/p97 proteins are targets of autophagic-lysosomal degradation", PLoS One, Vol.11, No.10 (SCI)
Erbil, Seçil and Oral, Özlem and Mitou, Geraldine and Kığ, Cenk and Durmaz, Emel and Güven-Maiorov, Emine and Gülaçtı, Ferah and Gökçe, Gökçen and Dengjel, Jön and Sezerman, Uğur and Gözüaçık, Devrim (2016) "RACK1 is an interaction partner of ATG5 and a novel regulator of autophagy", Journal of Biological Chemistry, Vol.291, No.32, 16753-16765 (SCI)
Tekirdağ Koşar, Kumsal Ayşe and Akkoç, Yunus and Koşar, Ali and Gözüaçık, Devrim (2016) "MIR376 family and cancer", Histology and Histopathology, Vol.31, No.8, 841-855 (SCI)
Ghorbani, Morteza and Yıldız, Mehmet and Gözüaçık, Devrim and Koşar, Ali (2016) "Cavitating nozzle flows in micro- and minichannels under the effect of turbulence", Journal of Mechanical Science and Technology, Vol.30, No.6, 2565-2581 (SCI)
Ghorbani, Morteza and Oral, Özlem and Ekici, Sinan and Gözüaçık, Devrim and Koşar, Ali (2016) "Review on lithotripsy and cavitation in urinary stone therapy", IEEE Reviews in Biomedical Engineering, Vol.9, 264-283
Oral, Özlem and Akkoç, Yunus and Bayraktar, Öznur and Gözüaçık, Devrim (2016) "Physiological and pathological significance of the molecular cross-talk between autophagy and apoptosis", Histology and Histopathology, Vol.31, No.5, 479-498 (SCI)
Klionsky, Daniel J. and Gözüaçık, Devrim and Budak, Hikmet and Autophagy, Consortium (2016) "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)", Autophagy, Vol.12, No.1, 1-222 (SCI)
Oral, Özlem and Çıkım, Taha Abdullah and Zuvin, Merve and Ünal, Özlem and Yağcı-Acar, Havva and Gözüaçık, Devrim and Koşar, Ali (2015) "Effect of varying magnetic fields on targeted gene delivery of nucleic acid-based molecules", Annals of Biomedical Engineering, Vol.43, No.11, 2816-2826 (SCI)
Üzüşen, Doğan and Demir, Ebru and Perk, Osman Yavuz and Oral, Özlem and Ekici, Sinan and Ünel, Mustafa and Gözüaçık, Devrim and Koşar, Ali (2015) "Assessment of probe-to-specimen distance effect in kidney stone treatment with hydrodynamic cavitation", Journal of Medical Devices, Vol.9, No.3 (SCI)
Duman, Fatma Demir and Hocaoğlu, İbrahim and Öztürk, Deniz Gülfem and Gözüaçık, Devrim and Kiraz, Alper and Yağcı Acar, Havva (2015) "Highly luminescent and cytocompatible cationic Ag2S NIR-emitting quantum dots for optical imaging and gene transfection", Nanoscale, Vol.7, No.26, 11352-11362 (SCI)
Küçükgül, Can and Özler, Saime Burçe and İnci, İlyas and Karakaş, Hacer Ezgi and Irmak, Ster and Gözüaçık, Devrim and Taralp, Alpay and Koç, Bahattin (2015) "3D bioprinting of biomimetic aortic vascular constructs with self-supporting cells", Biotechnology and Bioengineering, Vol.112, No.4, 811-821 (SCI)
Özbey, Arzu and Karimzadehkhouei, Mehrdad and Yalçın, Sinan Eren and Gözüaçık, Devrim and Koşar, Ali (2015) "Modeling of ferrofluid magnetic actuation with dynamic magnetic fields in small channels", Microfluidics and Nanofluidics, Vol.18, No.3, 447-460 (SCI)
Karakaş, Hacer Ezgi and Gözüaçık, Devrim (2014) "Autophagy and cancer", Turkish Journal of Biology, Vol.38, No.6, 720-739 (SCI)
Gözüaçık, Devrim and Yağcı-Acar, Havva Funda and Akkoç, Yunus and Koşar, Ali and Doğan-Ekici, Işın and Ekici, Sinan (2014) "Anticancer use of nanoparticles as nucleic acid carriers", Journal of Biomedical Nanotechnology (SI), Vol.10, No.9, 1751-1783 (SCI)
Çıkım, Taha Abdullah and Gözüaçık, Devrim and Koşar, Ali (2014) "Power reclamation efficiency of a miniature energy-harvesting device using external fluid flows", lnternational Journal of Energy Research, Vol.38, No.10, 1318-1330 (SCI)
Kurtoğlu, Evrim and Kaya, Alihan and Gözüaçık, Devrim and Acar, Funda Yağcı and Koşar, Ali (2014) "Experimental study on convective heat transfer performance of iron oxide based ferrofluids in microtubes", Journal of Thermal Science and Engineering Applications, Vol.6, No.3 (SCI)
Korkmaz, Gözde and Tekirdağ, Kumsal Ayşe and Özturk, Deniz Gülfem and Koşar, Ali and Sezerman, Uğur and Gözüaçık, Devrim (2013) "MIR376A is a regulator of starvation-induced autophagy", PLoS One, Vol.8, No.12 (SCI)
İtah, Zeynep and Oral, Özlem and Perk, Osman Yavuz and Şeşen, Muhsincan and Demir, Ebru and Erbil, Seçil and Doğan-Ekici, A. Işın and Ekici, Sinan and Koşar, Ali and Gözüaçık, Devrim (2013) "Hydrodynamic cavitation kills prostate cells and ablates benign prostatic hyperplasia tissue", Experimental Biology and Medicine, Vol.238, No.11, 1-9 (SCI)
Tekirdağ, Kumsal Ayşe and Özturk, Deniz Gülfem and Gözüaçık, Devrim (2013) "Alteration in autophagic-lysosomal potential during aging and neurological diseases: the microRNA perspective", Current Pathobiology Reports, Vol.1, No.4, 1-36
Tekirdağ, Kumsal Ayşe and Gözüaçık, Devrim (2013) "Role of miRNAs in the regulation of autophagy", Pakistan Journal of Clinical and Biomedical Research, Vol.1, No.2, 6-10
Erzurumlu, Yalçın and Aydın, Köse Fadime and Gözen, Oğuz and Gözüaçık, Devrim and Toth, Eric A. and Ballar, Petek (2013) "A unique IBMPFD-related P97/VCP mutation with differential binding pattern and subcellular localization", International Journal of Biochemistry and Cell Biology, Vol.45, No.4, 773-782 (SCI)
Tekirdağ, Kumsal Ayşe and Korkmaz, Gözde and Özturk, Deniz Gülfem and Agami, Reuven and Gözüaçık, Devrim (2013) "MIR181A regulates starvation- and rapamycin-induced autophagy through targeting of ATG5", Autophagy, Vol.9, No.3, 374-385 (SCI)
Perk, Osman Yavuz and Şeşen, Muhsincan and Gözüaçık, Devrim and Koşar, Ali (2012) "Kidney stone erosion by micro scale hydrodynamic cavitation and consequent kidney stone treatment", Annals of Biomedical Engineering, Vol.40, No.9, 1895-1902 (SCI)
Oral, Özlem and Öz-Arslan, Devrim and İtah, Zeynep and Naghavi, Atabak and Deveci, Remziye and Karaçalı, Sabire and Gözüaçık, Devrim (2012) "Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death", Apoptosis, Vol.17, No.8, 810-820 (SCI)
Kuzuoğlu, Duygu and Cebeci Yalçınkaya, Özge and Akpınar, Bala Anı and Mitou, Geraldine and Korkmaz, Gözde and Gözüaçık, Devrim and Budak, Hikmet (2012) "Autophagy-related gene, TdAtg8, in wild emmer wheat plays a role in drought and osmotic stress response", Planta, Vol.236, No.4, 1081-1092 (SCI)
Klionsky, Dan J. and Autophagy, Consortium and Gözüaçık, Devrim (2012) "Guidelines for the use and interpretation of assays for monitoring autophagy", Autophagy, Vol.8, No.4, 445-544 (SCI)
Korkmaz, Gözde and Le Sage, Carlos and Tekirdağ, Kumsal Ayşe and Agami, Reuven and Gözüaçık, Devrim (2012) "miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1", Autophagy, Vol.8, No.2, 165-176 (SCI)
Öz Arslan, Devrim and Korkmaz, Gözde and Gözüaçık, Devrim (2011) "Autophagy: a cellular stres and a cell death mechanism (Otofaji: bir hücresel stres yanıtı ve ölüm mekanizması)", Acıbadem Üniversitesi Sağlık Bilimleri Dergisi , Vol.2, No.4, 184-194
Koşar, Ali and Şeşen, Muhsincan and Oral, Özlem and İtah, Zeynep and Gözüaçık, Devrim (2011) "Bubbly cavitating flow generation and investigation of its erosional nature for biomedical applications", IEEE Transactions on Biomedical Engineering, Vol.58, No.5, 1337-1346 (SCI)
Mitou, Geraldine and Budak, Hikmet and Gözüaçık, Devrim (2009) "Techniques to study autophagy in plants", International Journal of Plant Genomics , Vol.2009, 1-14
Gözüaçık, Devrim and Bialik, S. and Raveh, T. and Mitou, Geraldine and Shohat, G. and Sabanay, H. and Mizushima, N. and Yoshimori, T. and Kimchi, A. (2008) "DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death.", Cell Death and Differentiation, Vol.15, No.12, 1875-1886 (SCI)
Book Section / Chapter
Arachiche, Amal and Gözüaçık, Devrim, "Regulation of autophagy in health and disease", Toxicity and Autophagy in Neurofegenerative Disorders, Fuentes, Jose M. (ed.), Switzerland: Springer, August 2015, 1-24
Gözüaçık, Devrim and Kığ, Cenk, "Cell death and autophagy: a historical perspective", 20 Years of Cell Death, Lockshin, Richard A. and Zakeri, Zahra (eds.), New York: International Cell Death Society, May 2015, 222-244
Tekirdağ, Kumsal Ayşe and Öztürk, Deniz Gülfem and Gözüaçık, Devrim, "Regulation of autophagy by microRNAs", Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Hayat, M. A. (ed.), The Netherlands: Elsevier Academic Press, January 2015, 85-101
Eberhart, Karin and Oral, Özlem and Gözüaçık, Devrim, "Induction of autophagic cell death by anticancer agents", Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, and Infection, and Aging, Hayat, M. A. (ed.), The Netherlands: Elsevier, October 2013, 179-202
Oral, Özlem and Irmak, Ster and Ekici, Sinan and Gözüaçık, Devrim, "Autophagy in urology (Ürolojide otofaji)", Moleküler Üroloji, Türkeri, Levent and Özer, Ayşe and Narter, Fehmi (eds.), İstanbul: Üroonkoloji Derneği Yayınları, November 2012, 271-283
Gözüaçık, Devrim, "Otofaji ve sinyal yolakları", II. Hücre Ölümü Araştırma Teknikleri Teorik Kursu, Koçtürk, Semra and Vatansever, H. Seda (eds.), Eskisehir: Eskisehir Osmangazi Üniversitesi, October 2012, 49-60
Gözüaçık, Devrim, "Otofaji analiz yöntemleri ve uygulama aşamaları", II. Hücre Ölümü Araştırma Teknikleri Teorik Kursu, Koçtürk, Semra and Vatansever, H. Seda (eds.), Eskisehir: Eskisehir Osmangazi Üniversitesi, October 2012, 133-146
Gözüaçık, Devrim, "Otofaji analiz yöntemleri ve uygulama aşamaları (Autophagy analysis techniques and applications)", Hücre Ölümü Araştırma Teknikleri , Koçtürk, Semra and Vatansever, H. Seda (eds.), Izmir: Dokuz Eylul University Press, November 2011, 129-141
Gözüaçık, Devrim, "Otofaji ve sinyal yolakları (Autophagy and signaling pathways)", Hücre Ölümü Araştırma Teknikleri, Koçtürk, Semra and Vatansever, H. Seda (eds.), Izmir: Dokuz Eylul University Press, November 2011, 53-61
Papers in Conference Proceedings
Oral, Özlem and Sarafi, Parisa and Yüce, Aysel and Gözüaçık, Devrim and Dökmeci, Serap, "Molecular mechanism of autophagic pathway in Gaucher cells", SSIEM Annual Symposium 2016, SSIEM, September 2016
Oral, Özlem and Bayraktar, Öznur and Yücel , Aysel and Dökmeci, Serap and Gözüaçık, Devrim, "Molecular significance of autophagy in Gaucher disease", 1st International Cell Death Research Congress, Cell Death Research Society, May 2016
Kim, Junyoung and Karakaş Schüller, Hacer Ezgi and Choi, Yongjun and Gözüaçık, Devrim and Cho, Yoon-Kyoung, "Monitoring single tumor interactions with fibroblasts in autophagy activation", 8th International Conference on Microtechnologies in Medicine and Biology (MMB), The Korean BioChip Society, April 2016, 135-136
Oral, Özlem and Demir, Hülya and Yüce, Aysel and Gözüaçık, Devrim and Dökmeci Emre, Serap, "Gaucher hastalığı patolojisinde otofaji moleküler mekanizması", V.Uluslararası Katılımlı Lizozomal Hastalıklar Kongresi, Çocuk Beslenme ve Metabolizma Derneği, April 2016
Kim, Junyoung and Karakaş Schüller, Hacer Ezgi and Choi, Yong-Jun and Gözüaçık, Devrim and Cho, Yoon-Kyoung, "Kinetic study of autophagy activation in fibroblasts interacted with single tumor cell in microfluidic platform", Annual Autumn Meeting of The Korean BioChip Society, Korean BioChip Society, November 2015, 126-126
Kim, Junyoung and Karakaş Schüller, Hacer Ezgi and Gözüaçık, Devrim and Cho, Yoon-Kyoung, "Single cell analysis on the role of TGF-β1 in autophagy of tumor cell-interacted stroma fibroblasts", 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015), Chemical and Biological Microsystems Society, October 2015, 358-360
Oral, Özlem and Yüce, Aysel and Dökmeci, Serap and Gözüaçık, Devrim, "Involvement of autophagy abnormalities in Gaucher lysosomal storage disease", ICDS (International Cell Death Society Presents): Implementation of the Knowledge of Cell Death, International Cell Death Society, May 2015
Üzüşen, Doğan and Oral, Özlem and Ekici, Sinan and Ünel, Mustafa and Gözüaçık, Devrim and Koşar, Ali, "Assessment of probe-to-specimen distance effect in kidney stone treatment with hydrodynamic cavitation", 4th European Conference on Microfluidics (Microfluidics 2014), Limerick, Ireland: University of Limerick, December 2014
Çıkım, Taha Abdullah and Oral, Özlem and Acar, Havva Funda Yagci and Gözüaçık, Devrim and Koşar, Ali, "Effect of varying magnetic fields on targeted gene delivery of nucleic acid-based molecules", 4th Micro and Nano Flows Conference (MNF2014), London, UK: University of City College London, October 2014
Oral, Özlem and Sarafi, Parisa and Yüce, Aysel and Dökmeci, Serap and Gözüaçık, Devrim, "Autophagy abnormalities in mutant cells isolated from Gaucher's lysosomal storage disease", FEBS Advanced Lecture Course 360° Lysosome: from Structure to Genomics, from Function to Disease, FEBS (Federation of European Biochemical Societies), October 2014
Oral, Özlem and Sarafi, Parisa and Yüce, Aysel and Gözüaçık, Devrim and Dökmeci, Serap, "Molecular and cellular analysis of autophagy in Gaucher disease (Gaucher hastalığında, otofaji mekanizması ve aktivitesinin moleküler ve hücresel düzeyde incelenmesi)", XIII. Ulusal Tıbbi Biyoloji ve Genetik Kongresi , Tıbbi Biyoloji Derneği, October 2013
Kurtoğlu, Evrim and Kaya, Alihan and Gözüaçık, Devrim and Acar, Funda Yağcı and Koşar, Ali, "Heat transfer enhancement with iron oxide nanoparticle based ferrofluids", 11th International Conference on Nanochannels, Microchannels, and Minichannels (ICNMM2013), New York, NY: ASME (American Society of Mechanical Engineers), July 2013
Küçükgül, Can and Özler, Saime Burçe and Karakaş, Hacer Ezgi and Gözüaçık, Devrim and Koç, Bahattin, "3D hybrid bioprinting of macrovascular structures", Bártolo, Paulo and Fernandes, Paulo (eds.), 3rd ECCOMAS Thematic Conference on Tissue Engineering (ICTE 2013), The Netherlands: Elsevier, June 2013, 183-192
Çıkım, Taha Abdullah and Koşar, Ali and Gözüaçık, Devrim and Tatar, Oğuz, "Power reclamation efficiency of a miniature energy harvesting device using internal fluid flows", ASME International Mechanical Engineering Congress and Exposition, New York, NY: ASME (American Society of Mechanical Engineers), November 2012
Çıkım, Taha Abdullah and Kaya, Alihan and Gözüaçık, Devrim and Koşar, Ali, "Power reclamation efficiency of a miniature energy harvesting device using internal fluid flows", Global Conference on Global Warming 2012, Berlin: Springer, July 2012
Gözüaçık, Devrim, "Autophagy, cell death and disease", 4th International Congress of Molecular Medicine, Stanford: Highwire, May 2011, 484-484
Koşar, Ali and Akbaş, Akın and Şahin, Ö. and Kubilay, Aytaç and Oral, Özlem and Gözüaçık, Devrim, "Bubbly cavitating flow generation and investigation of its erosional nature for biomedical applications", 2nd Micro and Nano Flows Conference, West London, UK: MNF2009, September 2009
Bilen, Hakan and Hocaoğlu, Muhammet Ali and Baran, Eray Abdurrahman and Ünel, Mustafa and Gözüaçık, Devrim, "Novel parameter estimation schemes in microsystems", IEEE International Conference on Robotics and Automation, USA: IEEE (Institute of Electrical and Electronics Engineers), March 2009, 2394-2399
Volumes Edited / Special Issues
Mehta, Rajendra and Geçkil, Hikmet and Gözüaçık, Devrim, Cancer: normal cells' reply to a deadly fate (Turkish Journal of Biology: Special Issue), Ankara, Turkey: TUBITAK (Scientific and Technological Research Council of Turkey), November 2014
Before SU Publications:

(Selected Publications)

 

Llambi F, Calheiros F, Gozuacik D, Pays L, Del Rio G, Kimchi A, Mehlen P. The dependence receptor UNC5H2 mediates apoptosis through DAP kinase. EMBO Journal, 2005 Mar 23;24(6):1192-201.

Shani G, Marash L, Gozuacik D, Bialik S, Teitelbaum L, Shohat G, Kimchi A. Death- associated protein kinase phosphorylates ZIP kinase, forming a unique kinase hierarchy to activate its cell death functions. Molecular and Cellular Biology, 2004 Oct;24(19):8611-26.

Gozuacik D and Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene, 2004 Apr 12;23(16):2891-906. Review.

Paterlini-Brechot P, Saigo K, Murakami Y, Chami M, Gozuacik D, Mugnier C, Lagorce D, Brechot C. Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene. Oncogene, 2003 Jun 19;22(25):3911-6.

Gozuacik D, ChamiM, Murakami Y, FaivreJ, LagorceD, Poch O, Biermann O, Knippers R, BréchotC, Paterlini-BréchotP. Identification and functional characterization of a new member of the human Mcm protein family: hMcm8. Nucleic Acids Research, 2003 Jan 15;31(2):570-9.

Gozuacik DMurakami Y, Saigo K, Chami M, Mugnier C, Lagorce D, Okanoue T, Urashima T, Brechot C, Paterlini-Brechot P. Identification of human cancer-related genes by naturally occurring Hepatitis B Virus DNA tagging. Oncogene, 2001 Sep 27;20(43):6233-40.

Chami M*Gozuacik D*, Lagorce D, Brini M, Falson P, Peaucellier G, Pinton P, Lecoeur H, Gougeon ML, le Maire M, Rizzuto R, Brechot C, Paterlini-Brechot P. SERCA1 truncated proteins unable to pump calcium reduce the endoplasmic reticulum calcium concentration and induce apoptosis. Journal of Cell Biology, 2001 Jun 11;153(6):1301-14.

Chami M*Gozuacik D*, Saigo K*, Capiod T, Falson P, Lecoeur H, Urashima T, Beckmann J, Gougeon ML, Claret M, le Maire M, Brechot C, Paterlini-Brechot P. Hepatitis B virus-related insertional mutagenesis implicates SERCA1 gene in the control of apoptosis. Oncogene, 2000 Jun 8;19(25):2877-86.